Role of intramuscular afferent fibers in the ventilatory response to dynamic exercise in humans

S. A. Smith, K. M. Gallagher, K. H. Bryant, R. G. Ouerry, P. B. Raven

Research output: Contribution to journalArticle

Abstract

Eight subjects, aged 26.5 ± 3.7 yrs, performed incremental workload cycling to investigate the interaction of skeletal muscle ergoreceptors in eliciting a ventilatory stimulus response to exercise. Each subject performed three bouts of exercise: control (exercise - no intervention); exercise with thigh cuff inflation to 90 mmHg (to reduce venous outflow and stimulate metaboreceptors); and exercise with application of lower-body positive pressure (LBPP) to 45 mmHg (to stimulate mechanoreceptors). Measurements of ventilation (VE, L·min-1), change in intramuscular pressure (ΔIMP, mmHg), and pH were collected. CONTROL CUFFS LBPP Watts VE pH ΔIMP VE pH ΔIMP VE pH ΔIMP Rest*14.3 7.38 0.0 13.9 7.38 0.0 13.9 7.38 0.0 67W 30.4 7.37 1.1 29.2 7.37 0.4 37.4 7.37 4.48*137W 48.7 7.36 1.7 51.0 7.37 1.3 57.7 7.36 48.9*200W 67.8 7.33 2.0 76.9a 7.36*1.8 90.9*7.36*50.1*(*Significance from control at p<0.05; a Significance from control, p =0.08; Rest*- no interventions. Mean data is presented.) From these data, we conclude that stimulation of ergoreceptors generates a ventilatory stimulus to exercise.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

Fingerprint

Inosine Monophosphate
breathing
exercise
Fibers
Pressure
Mechanoreceptors
Economic Inflation
Thigh
Workload
Ventilation
Muscle
mechanoreceptors
Skeletal Muscle
inflation
thighs
skeletal muscle

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Smith, S. A., Gallagher, K. M., Bryant, K. H., Ouerry, R. G., & Raven, P. B. (1997). Role of intramuscular afferent fibers in the ventilatory response to dynamic exercise in humans. FASEB Journal, 11(3).

Role of intramuscular afferent fibers in the ventilatory response to dynamic exercise in humans. / Smith, S. A.; Gallagher, K. M.; Bryant, K. H.; Ouerry, R. G.; Raven, P. B.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Smith, SA, Gallagher, KM, Bryant, KH, Ouerry, RG & Raven, PB 1997, 'Role of intramuscular afferent fibers in the ventilatory response to dynamic exercise in humans', FASEB Journal, vol. 11, no. 3.
Smith, S. A. ; Gallagher, K. M. ; Bryant, K. H. ; Ouerry, R. G. ; Raven, P. B. / Role of intramuscular afferent fibers in the ventilatory response to dynamic exercise in humans. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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