Role of isoprenoid metabolism in chemotactic peptide receptor-mediated G protein activation

Kenneth R. McLeish, Eleanor D. Lederer, Jon B. Klein

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The role of isoprenylation in formyl peptide receptor-mediated G protein activation was studied using plasma membranes isolated from normal HL-60 granulocytes and from cells in which isoprenylation was inhibited with mevastatin. Plasma membrane expression of formyl peptide receptors and G protein β subunits, but not α(i)2 and α(i)3, was significantly reduced by inhibition of isoprenylation. This reduced expression resulted in impaired basal and fMet-Leu-Phe-stimulated G protein activation.

Original languageEnglish (US)
Pages (from-to)763-770
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume197
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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