Role of leptin resistance in the development of obesity in older patients

Sophie Carter, Alexandre Caron, Denis Richard, Frédéric Picard

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue. Centrally, leptin controls food intake, energy expenditure, and fat distribution, whereas it controls (among several others) insulin sensitivity, free fatty acids (FFAs) oxidation, and lipolysis in the periphery. Aging is associated with important changes in both the distribution and the composition of adipose tissue. Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction. This redistribution of adipose tissue in favor of visceral fat influences negatively both longevity and healthy aging as shown in numerous animal models. These modifications observed during aging are also associated with leptin resistance. This resistance blunts normal central and peripheral functions of leptin, which leads to a decrease in neuroendocrine function and insulin sensitivity, an imbalance in energy regulation, and disturbances in lipid metabolism. Here, we review how age-related leptin resistance triggers metabolic disturbances and affects the longevity of obese patients. Furthermore, we discuss the potential impacts of leptin resistance on the decline of brown adipose tissue thermogenesis observed in elderly individuals.

Original languageEnglish (US)
Pages (from-to)829-844
Number of pages16
JournalClinical Interventions in Aging
Volume8
StatePublished - Jul 4 2013
Externally publishedYes

Fingerprint

Leptin
Obesity
Insulin Resistance
Adipose Tissue
Fats
Hormones
White Adipose Tissue
Brown Adipose Tissue
Intra-Abdominal Fat
Thermogenesis
Cell Aging
Lipolysis
Subcutaneous Fat
Lipid Metabolism
Nonesterified Fatty Acids
Adipocytes
Energy Metabolism
Animal Models
Eating
Insulin

Keywords

  • Aging
  • Brown adipose tissue
  • Insulin sensitivity
  • Leptin
  • Obesity

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Role of leptin resistance in the development of obesity in older patients. / Carter, Sophie; Caron, Alexandre; Richard, Denis; Picard, Frédéric.

In: Clinical Interventions in Aging, Vol. 8, 04.07.2013, p. 829-844.

Research output: Contribution to journalReview article

Carter, Sophie ; Caron, Alexandre ; Richard, Denis ; Picard, Frédéric. / Role of leptin resistance in the development of obesity in older patients. In: Clinical Interventions in Aging. 2013 ; Vol. 8. pp. 829-844.
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