@article{fd369291be8e455f961b4d161f94c251,
title = "Role of LXRs in control of lipogenesis",
abstract = "The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR plays a central role in cholesterol metabolism. The identification here of a synthetic, nonsteroidal LXR-selective agonist series represented by T0314407 and T0901317 revealed a novel physiological role of LXR. Oral administration of T0901317 to mice and hamsters showed that LXR activated the coordinate expression of major fatty acid biosynthetic genes (lipogenesis) and increased plasma triglyceride and phospholipid levels in both species. Complementary studies in cell culture and animals suggested that the increase in plasma lipids occurs via LXR-mediated induction of the sterol regulatory element-binding protein 1 (SREBP-1) lipogenic program.",
keywords = "Fatty acid, LXR, Lipogenesis, SREBP, Triglyceride",
author = "Schultz, {Joshua R.} and Hua Tu and Alvin Luk and Repa, {Joyce J.} and Medina, {Julio C.} and Leping Li and Susan Schwendner and Shelley Wang and Martin Thoolen and Mangelsdorf, {David J.} and Lustig, {Kevin D.} and Bei Shan",
note = "Funding Information: Substance P (SP) has recently been found in striatonigral neurons in the rat brain (I-3). Cell bodies of these neurons are situated largely in the more rostral aspects of the striatum (4-7) and project axons which terminate in the substantia nigra (I-3). In the substantia nigra, SP is concentrated in the synaptosomal and vesicular fractions (8) and can be released in vitro by potassium-induced depolarization in the presence of adequate amounts of calcium (9). Local application of SP to the substantia nigra evokes predominantly excitatory unit responses (10) and accelerates dopamine turnover (11) and release (12) in the ipsilateral striatum, Ipresent address: Department of Physiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20014. 2These studies were supported in part by a grant from the United States Public Health Service (AM-14228). D.J.P. was the recipient of predoctoral fellowships from the Whitaker Health Sciences Fund and the National Institute of Mental Health. 0024-3205/80/431593-10502.00/0 Copyright (c) 1980 Pergamon Press Ltd suggesting activation of the dopaminergic nigrostriatal tract. These findings suggest that SP, when released from striatonigral nerve terminals, may partly control the activity of dopamine-containing nigrostriatal neurons.",
year = "2000",
month = nov,
day = "15",
doi = "10.1101/gad.850400",
language = "English (US)",
volume = "14",
pages = "2831--2838",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "22",
}