Role of P-Glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge

Medicine & Life Sciences

• tanshinone 100%
• Salvia miltiorrhiza 92%
• Intestinal Absorption 77%
• ATP Binding Cassette Transporter, Subfamily B, Member 1 74%
• verapamil drug combination quinidine 26%
• Biological Availability 14%
• Liver Microsomes 11%
• verlukast 8%
• Probenecid 6%
• Vanadates 6%
• Digoxin 6%
• Caco-2 Cells 6%
• Angina Pectoris 5%
• Microsomes 5%
• Hyperlipidemias 5%
• Adenosine Triphosphatases 5%
• Inhibitory Concentration 50 4%
• Permeability 4%
• Pharmaceutical Preparations 4%
• China 4%
• Adenosine Triphosphate 4%
• Perfusion 3%
• Pharmacokinetics 3%
• Myocardial Infarction 3%
• Direction compound 3%
• Temperature 3%
• Stroke 3%
• Membranes 3%
• In Vitro Techniques 2%
• Proteins 1%
• Therapeutics 0%

Chemical Compounds

• Quinidine 69%
• Verapamil 66%
• Monolayer 50%
• Bioavailability 49%
• MK 571 32%
• Glycoprotein P Inhibitor 27%
• Pharmacological Metabolism 26%
• Probenecid 25%
• Digoxin 23%
• Vmax 18%
• Drug 17%
• Permeability 13%
• Pharmacokinetics 12%
• Metabolite 11%
• Protein 6%