Role of p38 and JNK in liver ischemia and reperfusion

Lashonda A. King, Alexander H. Toledo, Fernando A. Rivera-Chavez, Luis H. Toledo-Pereyra

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Background/purpose: The signal transduction of mitogen-activated protein kinases (MAPKs) has appeared to be an important mediator of ischemic-related events. Because of this, we analyzed the participation of p38 and JNK in liver ischemia and reperfusion, as two individual members of the MAPK family of proteins. Methods: All papers referred to in PubMed for the past 15 years were analyzed to determine how and when these MAPKs were considered to be an intricate part of the ischemic event. References were cross-studied to ascertain whether other papers could be found in the literature. Results: The role of p38 and JNK in liver ischemia was confirmed in the literature. The activation of these mediators was associated with the induction of apoptosis and necrosis. Inhibitors of p38 and JNK reduced the liver ischemia and reperfusion damage, probably through the mechanisms mentioned before. Conclusions: The development of effective inhibitors of p38 and JNK protein mediators is important for minimizing the harmful effects associated with liver ischemia and reperfusion.

Original languageEnglish (US)
Pages (from-to)763-770
Number of pages8
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume16
Issue number6
DOIs
StatePublished - Nov 1 2009

Keywords

  • Ischemia mediators
  • JNK
  • Liver ischemia
  • P38
  • Reperfusion

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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    King, L. A., Toledo, A. H., Rivera-Chavez, F. A., & Toledo-Pereyra, L. H. (2009). Role of p38 and JNK in liver ischemia and reperfusion. Journal of Hepato-Biliary-Pancreatic Surgery, 16(6), 763-770. https://doi.org/10.1007/s00534-009-0155-x