TY - JOUR
T1 - Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells
AU - Zhou, Yan Ting
AU - Shimabukuro, Michio
AU - Wang, May-Yun
AU - Lee, Young H
AU - Higa, Moritake
AU - Milburn Jr., Joseph Leslie
AU - Newgard, Christopher B.
AU - Unger, Roger H
PY - 1998/7/21
Y1 - 1998/7/21
N2 - Expression of peroxisome proliferator-activated receptor α (PPARα) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARα/retinoid x receptor ligands, and FA all up-regulate PPARα and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARα is a OB-R-dependent factor required for normal fat homeostasis in islet cells.
AB - Expression of peroxisome proliferator-activated receptor α (PPARα) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARα/retinoid x receptor ligands, and FA all up-regulate PPARα and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARα is a OB-R-dependent factor required for normal fat homeostasis in islet cells.
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U2 - 10.1073/pnas.95.15.8898
DO - 10.1073/pnas.95.15.8898
M3 - Article
C2 - 9671776
AN - SCOPUS:0032555148
SN - 0027-8424
VL - 95
SP - 8898
EP - 8903
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 15
ER -