Role of R-Ras in Cell Growth

Gretchen A. Repasky; Adrienne D. Cox; Ariella B. Hanker; Natalia Mitin; Channing J. Der

doi:10.1016/B978-0-12-374145-5.00214-X

Role of R-Ras in Cell Growth

Gretchen A. Repasky, Adrienne D. Cox, Ariella B. Hanker, Natalia Mitin, Channing J. Der

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.

Original language	English (US)
Title of host publication	Handbook of Cell Signaling, Second Edition
Publisher	Elsevier
Pages	1753-1762
Number of pages	10
Volume	2
ISBN (Electronic)	9780123741455
DOIs	https://doi.org/10.1016/B978-0-12-374145-5.00214-X
State	Published - Jan 1 2009
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-374145-5.00214-X

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title = "Role of R-Ras in Cell Growth",

abstract = "This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.",

author = "Repasky, {Gretchen A.} and Cox, {Adrienne D.} and Hanker, {Ariella B.} and Natalia Mitin and Der, {Channing J.}",

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AU - Repasky, Gretchen A.

AU - Cox, Adrienne D.

AU - Hanker, Ariella B.

AU - Mitin, Natalia

AU - Der, Channing J.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.

AB - This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.

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BT - Handbook of Cell Signaling, Second Edition

PB - Elsevier

ER -

Role of R-Ras in Cell Growth

Abstract

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