This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.
|Original language||English (US)|
|Title of host publication||Handbook of Cell Signaling, 2/e|
|Number of pages||10|
|State||Published - Dec 1 2010|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)