Role of r-ras in cell growth

Gretchen A. Repasky, Adrienne D. Cox, Ariella B. Hanker, Natalia Mitin, Channing J. Der

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.

Original languageEnglish (US)
Title of host publicationHandbook of Cell Signaling, 2/e
PublisherElsevier Inc.
Pages1753-1762
Number of pages10
Volume2
ISBN (Print)9780123741455
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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