Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease

Abhimanyu Garg, P. G. Gopinath, J. N. Pande, J. S. Guleria

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionnaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and 99mTc-radio aerosol-inhalation lung imaging. Perfusion lung imaging with 99mTc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P<0.001) was observed between the degree of abnormalities on radioaerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum midexpiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radioaerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalEuropean Journal Of Nuclear Medicine
Volume8
Issue number4
DOIs
StatePublished - Apr 1983

Fingerprint

Perfusion Imaging
Respiratory Function Tests
Aerosols
Radio
Chronic Obstructive Pulmonary Disease
Lung
Forced Expiratory Volume
Inhalation
Physical Examination
Albumins
Thorax
Perfusion
X-Rays

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease. / Garg, Abhimanyu; Gopinath, P. G.; Pande, J. N.; Guleria, J. S.

In: European Journal Of Nuclear Medicine, Vol. 8, No. 4, 04.1983, p. 167-171.

Research output: Contribution to journalArticle

@article{34b06b7f8c81407693ae4958fd76ddef,
title = "Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease",
abstract = "The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionnaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and 99mTc-radio aerosol-inhalation lung imaging. Perfusion lung imaging with 99mTc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P<0.001) was observed between the degree of abnormalities on radioaerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum midexpiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radioaerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.",
author = "Abhimanyu Garg and Gopinath, {P. G.} and Pande, {J. N.} and Guleria, {J. S.}",
year = "1983",
month = "4",
doi = "10.1007/BF00252889",
language = "English (US)",
volume = "8",
pages = "167--171",
journal = "European Journal Of Nuclear Medicine",
issn = "0340-6997",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease

AU - Garg, Abhimanyu

AU - Gopinath, P. G.

AU - Pande, J. N.

AU - Guleria, J. S.

PY - 1983/4

Y1 - 1983/4

N2 - The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionnaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and 99mTc-radio aerosol-inhalation lung imaging. Perfusion lung imaging with 99mTc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P<0.001) was observed between the degree of abnormalities on radioaerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum midexpiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radioaerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.

AB - The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionnaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and 99mTc-radio aerosol-inhalation lung imaging. Perfusion lung imaging with 99mTc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P<0.001) was observed between the degree of abnormalities on radioaerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum midexpiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radioaerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.

UR - http://www.scopus.com/inward/record.url?scp=0020524274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020524274&partnerID=8YFLogxK

U2 - 10.1007/BF00252889

DO - 10.1007/BF00252889

M3 - Article

C2 - 6222899

AN - SCOPUS:0020524274

VL - 8

SP - 167

EP - 171

JO - European Journal Of Nuclear Medicine

JF - European Journal Of Nuclear Medicine

SN - 0340-6997

IS - 4

ER -