Role of resistin in obesity, insulin resistance and Type II diabetes

Christine M. Kusminski, Philip G. McTernan, Sudhesh Kumar

Research output: Contribution to journalReview article

208 Citations (Scopus)

Abstract

Resistin is a member of a class of cysteine-rich proteins collectively termed resistin-like molecules. Resistin has been implicated in the pathogenesis of obesity-mediated insulin resistance and T2DM (Type II diabetes mellitus), at least in rodent models. In addition, resistin also appears to be a pro-inflammatory cytokine. Taken together, resistin, like many other adipocytokines, may possess a dual role in contributing to disease risk. However, to date there has been considerable controversy surrounding this 12.5 kDa polypeptide in understanding its physiological relevance in both human and rodent systems. Furthermore, this has led some to question whether resistin represents an important pathogenic factor in the aetiology of T2DM and cardiovascular disease. Although researchers still remain divided as to the role of resistin, this review will place available data on resistin in the context of our current knowledge of the pathogenesis of obesity-mediated diabetes, and discuss key controversies and developments.

Original languageEnglish (US)
Pages (from-to)243-256
Number of pages14
JournalClinical Science
Volume109
Issue number3
DOIs
StatePublished - Sep 1 2005

Fingerprint

Resistin
Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Rodentia
Adipokines
Cysteine
Cardiovascular Diseases
Research Personnel
Cytokines
Peptides

Keywords

  • Adipocytokine
  • Inflammation
  • Insulin resistance
  • Obesity
  • Resistin
  • Type II diabetes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Role of resistin in obesity, insulin resistance and Type II diabetes. / Kusminski, Christine M.; McTernan, Philip G.; Kumar, Sudhesh.

In: Clinical Science, Vol. 109, No. 3, 01.09.2005, p. 243-256.

Research output: Contribution to journalReview article

Kusminski, Christine M. ; McTernan, Philip G. ; Kumar, Sudhesh. / Role of resistin in obesity, insulin resistance and Type II diabetes. In: Clinical Science. 2005 ; Vol. 109, No. 3. pp. 243-256.
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