Role of solute excretion in prevention of norepinephrine-induced acute renal failure

R. W. Schrier, R. E. Cronin, P. Miller, A. de Torrenté, T. Burke, R. Bulger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Infusion of 0.75 μg/kg bw/min norepinephrine (NE), for 40 minutes, into one renal artery in anesthetized dogs, induced acute renal failure (ARF). Subsequently there was nearly complete reversal of function within 8 weeks. Isotonic saline volume expansion, or renal vasodilation plus diuresis by acetylcholine (into renal artery: 20 μg/min), did not protect against this type of ARF. Volume expansion with either 5 or 20 percent mannitol partly prevented the fall of GFR 3 hours after NE, this protection being correlated with the magnitude of the osmolar clearance at the time of the insult. IV furosemide (10 mg/kg + 10 mg/kg/h; fluid losses replaced) afforded an even better protection. Proximal tubular necrosis in the 'protected' kidneys was as severe as in non-protected kidneys. Glomerular cell morphology (scanning electron microscopy) was not altered by the 40-minute NE infusions. Functional 'protection' appeared to depend on solute diuresis at the time of insult.

Original languageEnglish (US)
Pages (from-to)355-359
Number of pages5
JournalYale Journal of Biology and Medicine
Volume51
Issue number3
StatePublished - 1978

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Acute Kidney Injury
Norepinephrine
Diuresis
Renal Artery
Kidney
Furosemide
Mannitol
Vasodilation
Electron Scanning Microscopy
Acetylcholine
Necrosis
Dogs
Scanning electron microscopy
Fluids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Schrier, R. W., Cronin, R. E., Miller, P., de Torrenté, A., Burke, T., & Bulger, R. (1978). Role of solute excretion in prevention of norepinephrine-induced acute renal failure. Yale Journal of Biology and Medicine, 51(3), 355-359.

Role of solute excretion in prevention of norepinephrine-induced acute renal failure. / Schrier, R. W.; Cronin, R. E.; Miller, P.; de Torrenté, A.; Burke, T.; Bulger, R.

In: Yale Journal of Biology and Medicine, Vol. 51, No. 3, 1978, p. 355-359.

Research output: Contribution to journalArticle

Schrier, RW, Cronin, RE, Miller, P, de Torrenté, A, Burke, T & Bulger, R 1978, 'Role of solute excretion in prevention of norepinephrine-induced acute renal failure', Yale Journal of Biology and Medicine, vol. 51, no. 3, pp. 355-359.
Schrier RW, Cronin RE, Miller P, de Torrenté A, Burke T, Bulger R. Role of solute excretion in prevention of norepinephrine-induced acute renal failure. Yale Journal of Biology and Medicine. 1978;51(3):355-359.
Schrier, R. W. ; Cronin, R. E. ; Miller, P. ; de Torrenté, A. ; Burke, T. ; Bulger, R. / Role of solute excretion in prevention of norepinephrine-induced acute renal failure. In: Yale Journal of Biology and Medicine. 1978 ; Vol. 51, No. 3. pp. 355-359.
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