Role of telomeres and telomerase in aging and cancer

Research output: Contribution to journalReview article

133 Citations (Scopus)

Abstract

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is the ability for continuous cell divisions that almost universally correlates with the stabilization of telomere length by the reactivation of telomerase. The repression of telomerase and shorter telomeres in humans may have evolved, in part, as an anticancer protection mechanism. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. This review focuses on the current state of advances in the telomerase area, identifies outstanding questions, and addresses areas and methods that need refinement. Significance: Despite many recent advances, telomerase remains a challenging target for cancer therapy. There are few telomerase-directed therapies, and many of the assays used to measure telomeres and telomerase have serious limitations. This review provides an overview of the current state of the field and how recent advances could affect future research and treatment approaches.

Original languageEnglish (US)
Pages (from-to)584-593
Number of pages10
JournalCancer Discovery
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2016

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Telomerase
Telomere
Neoplasms
Telomere Shortening
Cell Division
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Role of telomeres and telomerase in aging and cancer. / Shay, Jerry W.

In: Cancer Discovery, Vol. 6, No. 6, 01.06.2016, p. 584-593.

Research output: Contribution to journalReview article

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