Role of the aggresome pathway in cancer: Targeting histone deacetylase 6-dependent protein degradation

Agustin Rodriguez-Gonzalez, Tara Lin, Alan K. Ikeda, Tiffany Simms-Waldrip, Cecilia Fu, Kathleen M. Sakamoto

Research output: Contribution to journalReview article

128 Scopus citations

Abstract

Misfolded or aggregated proteins have two fates: they are either refolded with the help of chaperones or degraded by the proteasome. Cells also have an alternative pathway that involves intracellular "storage bins" for misfolded intracellular proteins known as aggresomes. Aggresomes recruit motor proteins that transport misfolded or aggregated proteins to chaperones and proteasomes for subsequent destruction. There is emerging evidence that inhibiting the aggresome pathway leads to accumulation of misfolded proteins and apoptosis in tumor cells through autophagy. We discuss the role of aggresomes in cancer and the potential to target this pathway for therapy.

Original languageEnglish (US)
Pages (from-to)2557-2560
Number of pages4
JournalCancer Research
Volume68
Issue number8
DOIs
StatePublished - Apr 15 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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