TY - JOUR
T1 - Role of the aggresome pathway in cancer
T2 - Targeting histone deacetylase 6-dependent protein degradation
AU - Rodriguez-Gonzalez, Agustin
AU - Lin, Tara
AU - Ikeda, Alan K.
AU - Simms-Waldrip, Tiffany
AU - Fu, Cecilia
AU - Sakamoto, Kathleen M.
PY - 2008/4/15
Y1 - 2008/4/15
N2 - Misfolded or aggregated proteins have two fates: they are either refolded with the help of chaperones or degraded by the proteasome. Cells also have an alternative pathway that involves intracellular "storage bins" for misfolded intracellular proteins known as aggresomes. Aggresomes recruit motor proteins that transport misfolded or aggregated proteins to chaperones and proteasomes for subsequent destruction. There is emerging evidence that inhibiting the aggresome pathway leads to accumulation of misfolded proteins and apoptosis in tumor cells through autophagy. We discuss the role of aggresomes in cancer and the potential to target this pathway for therapy.
AB - Misfolded or aggregated proteins have two fates: they are either refolded with the help of chaperones or degraded by the proteasome. Cells also have an alternative pathway that involves intracellular "storage bins" for misfolded intracellular proteins known as aggresomes. Aggresomes recruit motor proteins that transport misfolded or aggregated proteins to chaperones and proteasomes for subsequent destruction. There is emerging evidence that inhibiting the aggresome pathway leads to accumulation of misfolded proteins and apoptosis in tumor cells through autophagy. We discuss the role of aggresomes in cancer and the potential to target this pathway for therapy.
UR - http://www.scopus.com/inward/record.url?scp=42349091446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42349091446&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-07-5989
DO - 10.1158/0008-5472.CAN-07-5989
M3 - Review article
C2 - 18413721
AN - SCOPUS:42349091446
SN - 0008-5472
VL - 68
SP - 2557
EP - 2560
JO - Cancer research
JF - Cancer research
IS - 8
ER -