Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice

Bianka Brunne, Santos Franco, Elisabeth Bouché, Joachim Herz, Brian W. Howell, Jasmine Pahle, Ulrich Müller, Petra May, Michael Frotscher, Hans H. Bock

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

During dentate gyrus development, the early embryonic radial glial scaffold is replaced by a secondary glial scaffold around birth. In contrast to neocortical and early dentate gyrus radial glial cells, these postnatal glial cells are severely altered with regard to position and morphology in reeler mice lacking the secreted protein Reelin. In this study, we focus on the functional impact of these defects. Most radial glial cells throughout the nervous system serve as scaffolds for migrating neurons and precursor cells for both neurogenesis and gliogenesis. Precursor cell function has been demonstrated for secondary radial glial cells but the exact function of these late glial cells in granule cell migration and positioning is not clear. No data exist concerning the interplay between granule neurons and late radial glial cells during dentate gyrus development. Herein, we show that despite the severe morphological defects in the reeler dentate gyrus, the precursor function of secondary radial glial cells is not impaired during development in reeler mice. In addition, selective ablation of Disabled-1, an intracellular adaptor protein essential for Reelin signaling, in neurons but not in glial cells allowed us to distinguish effects of Reelin signaling on radial glial cells from possible secondary effects based on defective granule cells positioning.

Original languageEnglish (US)
Pages (from-to)1347-1363
Number of pages17
JournalGLIA
Volume61
Issue number8
DOIs
StatePublished - Aug 2013

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Ependymoglial Cells
Dentate Gyrus
Neuroglia
Neurologic Mutant Mice
Neurons
Neurogenesis
Nervous System
Cell Movement
Parturition

Keywords

  • Development
  • Differentiation
  • Gliogenesis
  • Hippocampus
  • reeler

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice. / Brunne, Bianka; Franco, Santos; Bouché, Elisabeth; Herz, Joachim; Howell, Brian W.; Pahle, Jasmine; Müller, Ulrich; May, Petra; Frotscher, Michael; Bock, Hans H.

In: GLIA, Vol. 61, No. 8, 08.2013, p. 1347-1363.

Research output: Contribution to journalArticle

Brunne, B, Franco, S, Bouché, E, Herz, J, Howell, BW, Pahle, J, Müller, U, May, P, Frotscher, M & Bock, HH 2013, 'Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice', GLIA, vol. 61, no. 8, pp. 1347-1363. https://doi.org/10.1002/glia.22519
Brunne, Bianka ; Franco, Santos ; Bouché, Elisabeth ; Herz, Joachim ; Howell, Brian W. ; Pahle, Jasmine ; Müller, Ulrich ; May, Petra ; Frotscher, Michael ; Bock, Hans H. / Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice. In: GLIA. 2013 ; Vol. 61, No. 8. pp. 1347-1363.
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