Role of trastuzumab in the adjuvant treatment of HER2-positive early breast cancer

Bushra Haq, Charles E. Geyer

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Amplification of the human epidermal growth factor receptor 2 (HER2) gene occurs in 18-23% of invasive breast carcinomas and is associated with a worse prognosis. This novel transforming gene was identified in 1985, and in 1987 HER2 amplification was demonstrated to be central to the aggressive, malignant phenotype of these cancers and a significant predictor of both time to relapse and overall survival. These observations led to the development of the first monoclonal antibody targeting the extracellular domain of HER2, trastuzumab (Herceptin®, Genentech and Hoffman LaRoche, Switzerland), which was approved by the US FDA for metastatic breast cancer in 1998. In 2005, results from four major trastuzumab adjuvant trials demonstrated a marked reduction in risk of recurrence, and trastuzumab is now an essential component of the adjuvant treatment of HER2-positive early breast cancer. Concerns regarding cardiac safety and mechanisms of resistance to trastuzumab remain important issues and are being addressed in ongoing research efforts.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalWomen's Health
Volume5
Issue number2
DOIs
StatePublished - Aug 14 2009

Keywords

  • Adjuvant therapy
  • Anthracyclines
  • Breast cancer
  • Cardiotoxicity
  • HER2 positive
  • Trastuzumab

ASJC Scopus subject areas

  • Medicine(all)

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