TY - JOUR
T1 - Role of ultrasonography of regional nodal basins in staging triple-negative breast cancer and implications for Local-Regional Treatment Part of the findings herein were presented at the 56th Annual Meeting of the American Society of Radiation Oncology, San Francisco, CA, Sep 2014.
AU - Shaitelman, Simona F.
AU - Tereffe, Welela
AU - Dogan, Basak E.
AU - Hess, Kenneth R.
AU - Caudle, Abigail S.
AU - Valero, Vicente
AU - Stauder, Michael C.
AU - Krishnamurthy, Savitri
AU - Candelaria, Rosalind P.
AU - Strom, Eric A.
AU - Woodward, Wendy A.
AU - Hunt, Kelly K.
AU - Buchholz, Thomas A.
AU - Whitman, Gary J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Purpose We sought to determine the rate at which regional nodal ultrasonography would increase the nodal disease stage in patients with triple-negative breast cancer (TNBC) beyond the clinical stage determined by physical examination and mammography alone, and significantly affect the treatments delivered to these patients. Methods and Materials We retrospectively reviewed the charts of women with stages I to III TNBC who underwent physical examination, mammography, breast and regional nodal ultrasonography with needle biopsy of abnormal nodes, and definitive local-regional treatment at our institution between 2004 and 2011. The stages of these patients' disease with and without ultrasonography of the regional nodal basins were compared using the Pearson χ2 test. Definitive treatments of patients whose nodal disease was upstaged on the basis of ultrasonographic findings were compared to those of patients whose disease stage remained the same. Results A total of 572 women met the study requirements. In 111 (19.4%) of these patients, regional nodal ultrasonography with needle biopsy resulted in an increase in disease stage from the original stage by physical examination and mammography alone. Significantly higher percentages of patients whose nodal disease was upstaged by ultrasonographic findings compared to that in patients whose disease was not upstaged underwent neoadjuvant systemic therapy (91.9% and 51.2%, respectively; P<.0001), axillary lymph node dissection (99.1% and 34.5%, respectively; P<.0001), and radiation to the regional nodal basins (88.2% and 29.1%, respectively; P<.0001). Conclusions Regional nodal ultrasonography in TNBC frequently changes the initial clinical stage and plays an important role in treatment planning.
AB - Purpose We sought to determine the rate at which regional nodal ultrasonography would increase the nodal disease stage in patients with triple-negative breast cancer (TNBC) beyond the clinical stage determined by physical examination and mammography alone, and significantly affect the treatments delivered to these patients. Methods and Materials We retrospectively reviewed the charts of women with stages I to III TNBC who underwent physical examination, mammography, breast and regional nodal ultrasonography with needle biopsy of abnormal nodes, and definitive local-regional treatment at our institution between 2004 and 2011. The stages of these patients' disease with and without ultrasonography of the regional nodal basins were compared using the Pearson χ2 test. Definitive treatments of patients whose nodal disease was upstaged on the basis of ultrasonographic findings were compared to those of patients whose disease stage remained the same. Results A total of 572 women met the study requirements. In 111 (19.4%) of these patients, regional nodal ultrasonography with needle biopsy resulted in an increase in disease stage from the original stage by physical examination and mammography alone. Significantly higher percentages of patients whose nodal disease was upstaged by ultrasonographic findings compared to that in patients whose disease was not upstaged underwent neoadjuvant systemic therapy (91.9% and 51.2%, respectively; P<.0001), axillary lymph node dissection (99.1% and 34.5%, respectively; P<.0001), and radiation to the regional nodal basins (88.2% and 29.1%, respectively; P<.0001). Conclusions Regional nodal ultrasonography in TNBC frequently changes the initial clinical stage and plays an important role in treatment planning.
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U2 - 10.1016/j.ijrobp.2015.05.015
DO - 10.1016/j.ijrobp.2015.05.015
M3 - Article
C2 - 26279028
AN - SCOPUS:84939443463
SN - 0360-3016
VL - 93
SP - 102
EP - 110
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 1
ER -