Role of VEGF-A in vascularization of pancreatic islets

Eckhard Lammert, Guqiang Gu, Margaret McLaughlin, Dennis Brown, Rolf Brekken, Lewis Charles Murtaugh, Hans Peter Gerber, Napoleone Ferrara, Douglas A. Melton

Research output: Contribution to journalArticle

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Abstract

Blood vessel endothelium has been recently shown to induce endocrine pancreatic development [1]. Because pancreatic endocrine cells or islets express high levels of vascular endothelial growth factors, VEGFs [2, 3], we investigated the role of a particular VEGF, VEGF-A, on islet vascularization and islet function. By deleting VEGF-A in the mouse pancreas, we show that endocrine cells signal back to the adjacent endothelial cells to induce the formation of a dense network of fenestrated capillaries in islets. Interestingly, VEGF-A is not required for the development of all islet capillaries. However, the few remaining capillaries found in the VEGF-A-deficient islets are not fenestrated and contain an unusual number of caveolae. In addition, glucose tolerance tests reveal that the VEGF-A-induced capillary network is not strictly required for blood glucose control but is essential for fine-tuning blood glucose regulation. In conclusion, we speculate that islet formation takes place in two sequential steps: in the first step, signals from blood vessel endothelium induce islet formation next to the vessels, and in the second step, the islets signal to the endothelium. The second step involves paracrine VEGF-A signaling to elaborate the interaction of islets with the circulatory system.

Original languageEnglish (US)
Pages (from-to)1070-1074
Number of pages5
JournalCurrent Biology
Volume13
Issue number12
DOIs
StatePublished - Jun 17 2003

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vascular endothelial growth factor A
islets of Langerhans
Islets of Langerhans
Vascular Endothelial Growth Factor A
endothelium
Vascular Endothelial Growth Factors
Endothelium
Endocrine Cells
blood vessels
Blood vessels
blood glucose
Blood Vessels
Blood Glucose
circulatory system
Cells
vascular endothelial growth factors
Caveolae
pancreas
Endothelial cells
endothelial cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Lammert, E., Gu, G., McLaughlin, M., Brown, D., Brekken, R., Murtaugh, L. C., ... Melton, D. A. (2003). Role of VEGF-A in vascularization of pancreatic islets. Current Biology, 13(12), 1070-1074. https://doi.org/10.1016/S0960-9822(03)00378-6

Role of VEGF-A in vascularization of pancreatic islets. / Lammert, Eckhard; Gu, Guqiang; McLaughlin, Margaret; Brown, Dennis; Brekken, Rolf; Murtaugh, Lewis Charles; Gerber, Hans Peter; Ferrara, Napoleone; Melton, Douglas A.

In: Current Biology, Vol. 13, No. 12, 17.06.2003, p. 1070-1074.

Research output: Contribution to journalArticle

Lammert, E, Gu, G, McLaughlin, M, Brown, D, Brekken, R, Murtaugh, LC, Gerber, HP, Ferrara, N & Melton, DA 2003, 'Role of VEGF-A in vascularization of pancreatic islets', Current Biology, vol. 13, no. 12, pp. 1070-1074. https://doi.org/10.1016/S0960-9822(03)00378-6
Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC et al. Role of VEGF-A in vascularization of pancreatic islets. Current Biology. 2003 Jun 17;13(12):1070-1074. https://doi.org/10.1016/S0960-9822(03)00378-6
Lammert, Eckhard ; Gu, Guqiang ; McLaughlin, Margaret ; Brown, Dennis ; Brekken, Rolf ; Murtaugh, Lewis Charles ; Gerber, Hans Peter ; Ferrara, Napoleone ; Melton, Douglas A. / Role of VEGF-A in vascularization of pancreatic islets. In: Current Biology. 2003 ; Vol. 13, No. 12. pp. 1070-1074.
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