Roles of Caspases in Necrotic Cell Death

Junying Yuan; Ayaz Najafov; Bénédicte F. Py

doi:10.1016/j.cell.2016.11.047

Roles of Caspases in Necrotic Cell Death

Junying Yuan, Ayaz Najafov, Bénédicte F. Py

Research output: Contribution to journal › Review article › peer-review

216 Scopus citations

Abstract

Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.

Original language	English (US)
Pages (from-to)	1693-1704
Number of pages	12
Journal	Cell
Volume	167
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2016.11.047
State	Published - Dec 15 2016
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2016.11.047

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title = "Roles of Caspases in Necrotic Cell Death",

abstract = "Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.",

author = "Junying Yuan and Ayaz Najafov and Py, {B{\'e}n{\'e}dicte F.}",

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N2 - Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.

AB - Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.

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Roles of Caspases in Necrotic Cell Death

Abstract

ASJC Scopus subject areas

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