Roles of Caspases in Necrotic Cell Death

Junying Yuan, Ayaz Najafov, Bénédicte F. Py

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations

Abstract

Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.

Original languageEnglish (US)
Pages (from-to)1693-1704
Number of pages12
JournalCell
Volume167
Issue number7
DOIs
StatePublished - Dec 15 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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