Roles of cholesterol and lipids in the etiopathogenesis of alzheimer's disease

Leonel Rojo, Marcela Sjöberg, Paula Hernández, Cristian Zambrano, Ricardo Maccioni

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of death in developed economies.This brain disorder is characterized by the formation of brain protein aggregates, namely, the paired helical filaments and senile plaques. Oxidative stress during life, neuroinflamamtion,and alterations in neuron-glia interaction patterns have been also involved in the etiopathogenesis of this disease. In recent years,cumulative evidence has been gained on the involvement of alteration in neuronal lipoproteins activity, as well as on the role of cholesterol and other lipids in the pathogenesis of this neurodegenerative disorder. In this review, we analyze the links between changes in cholesterol homeostasis, and the changes of lipids of major importance for neuronal activity and Alheimer's disease. The investigation on the fine molecular mechanisms underlying the lipids influence in the etiopathogenesis of Alzheimer's disease may shed light into its treatment and medical management.

Original languageEnglish (US)
Article number73976
JournalJournal of Biomedicine and Biotechnology
Volume2006
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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