Rosai-Dorfman disease (RDD) is a rare, acquired disease of unknown etiology that affects primarily chifdren and young adults. It is characterized by a proliferation of distinctive histiocytes in the lymph nodes and/or extranodal sites, involvement of the gastrointestinal tract is rare. We report a case of RDD in a 60-year-old woman who presented with hematochezia and was found to have RDD of the rectum presenting as a rectal mass. This report highlights the current pathogenetic mechanisms, immunohistochemical markers, and the gastrointestinal manifestations of RDD.
- Gastrointestinal tract
- Rosai-Dorfman disease
- Sinus histiocytosis with massive lymphadenopathy
ASJC Scopus subject areas
- Pathology and Forensic Medicine