@inproceedings{59ac264886ef45a5af74e8b05f4518bf,
title = "Rotational dynamics and polarization anisotropy of bound and unbound receptor-targeted contrast agents in cancerous and normal prostate tissues studied by time-resolved fluorescence spectroscopy",
abstract = "Temporal profiles of polarized fluorescence emitted from receptor-targeted contrast agents: Cybesin and Cytate, in prostate tissues were studied using ultrafast time-resolved spectroscopy. An analytical model was developed and used to investigate rotational dynamics and fluorescence polarization anisotropies of the contrast agents in prostate tissues from the measured data. The differences of rotational times and polarization anisotropies were observed for Cybesin (Cytate) in cancerous and normal prostate tissues, which reflect changes of micro-structures of cancerous and normal tissues, and their different bound affinity with contrast agents. This research may be used to develop better optical methods for in situ prostate cancer detection.",
keywords = "Polarization anisotropy, Prostate cancer receptor-targeted contrast agents, Rotation time, Time-resolved fluorescence polarization kinetics",
author = "Y. Pu and Wang, {W. B.} and S. Achilefu and Alfano, {R. R.}",
year = "2010",
doi = "10.1117/12.840775",
language = "English (US)",
isbn = "9780819479570",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Biopsy VII",
note = "Optical Biopsy VII ; Conference date: 25-01-2010 Through 28-01-2010",
}