Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

Jon S. Blevins; Haijun Xu; Ming He; Michael V. Norgard; Larry Reitzer; X. Frank Yang

doi:10.1128/JB.01721-08

Rrp2, a σ ⁵⁴-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

Jon S. Blevins, Haijun Xu, Ming He, Michael V. Norgard, Larry Reitzer, X. Frank Yang

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Rrp2 is the sole σ ⁵⁴-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates σ ⁵⁴-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other σ ⁵⁴-dependent transcriptional activators.

Original language	English (US)
Pages (from-to)	2902-2905
Number of pages	4
Journal	Journal of bacteriology
Volume	191
Issue number	8
DOIs	https://doi.org/10.1128/JB.01721-08
State	Published - Apr 2009

ASJC Scopus subject areas

Microbiology
Molecular Biology

Access to Document

10.1128/JB.01721-08

Cite this

@article{896025ec54df4e5fa1cb57a6cf170981,

title = "Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner",

abstract = "Rrp2 is the sole σ 54-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates σ 54-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other σ 54-dependent transcriptional activators.",

author = "Blevins, {Jon S.} and Haijun Xu and Ming He and Norgard, {Michael V.} and Larry Reitzer and Yang, {X. Frank}",

year = "2009",

month = apr,

doi = "10.1128/JB.01721-08",

language = "English (US)",

volume = "191",

pages = "2902--2905",

journal = "Journal of bacteriology",

issn = "0021-9193",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

AU - Blevins, Jon S.

AU - Xu, Haijun

AU - He, Ming

AU - Norgard, Michael V.

AU - Reitzer, Larry

AU - Yang, X. Frank

PY - 2009/4

Y1 - 2009/4

N2 - Rrp2 is the sole σ 54-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates σ 54-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other σ 54-dependent transcriptional activators.

AB - Rrp2 is the sole σ 54-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates σ 54-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other σ 54-dependent transcriptional activators.

UR - http://www.scopus.com/inward/record.url?scp=65249171323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249171323&partnerID=8YFLogxK

U2 - 10.1128/JB.01721-08

DO - 10.1128/JB.01721-08

M3 - Article

C2 - 19201806

AN - SCOPUS:65249171323

SN - 0021-9193

VL - 191

SP - 2902

EP - 2905

JO - Journal of bacteriology

JF - Journal of bacteriology

IS - 8

ER -

Rrp2, a σ ⁵⁴-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this