Ruptured arterial aneurysm of the kidney in a patient with microscopic polyangiitis

Noriko Tamei, Hidekazu Sugiura, Takashi Takei, Mitsuyo Itabashi, Keiko Uchida, Kosaku Nitta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We present the case of a 55-year-old man with ruptured arterial aneurysm accompanied by microscopic polyangiitis in the kidney. He was admitted to our hospital because of general fatigue, fever and serious numbness of his extremities. Microscopic polyangiitis (MPA) was diagnosed on the basis of cardinal symptoms, including rapidly progressive glomerular nephritis, peripheral nerve disorder and the lung abnormality, as well as positive MPO-ANCA findings. Hemodialysis had to be started on admission because of renal failure. Renal biopsy demonstrated necrotizing glomeruli, crescent formation with interstitial infiltrates. There were no immune deposits on immunofluorescence study or electron micrographs. The pathological diagnosis was necrotizing glomerulonephritis involving small and medium-sized arteries. He was treated with intravenous semi-pulse methylprednisolone therapy because of the intensely pathological xenal activation and the abnormal shadow on chest X-ray. The inflammatory reaction subsequently improved, MPO-ANCA decreased and the lung lesions diminished. He complained of sharp pain of sudden onset on his left side. His hemoglobin dropped from 9.8 g/dl to 6.0 g/dl developed in the subsequent hours, but there were no sign of hemorrhage. Abdominal CT scan showed a large left-sided perinephric, intracapsular hematoma. Selective arterial angiography showed multiple aneurysms in renal and hepatic arteries. No active bleeding was present and he recovered with transfusion, supportive therapy and monitoring alone. Multiple aneurysms detected by angiography in the renal and hepatic arteries showed improvement. He is currently stable on regular hemodialysis treatment with a low dose of oral prednisolone.

Original languageEnglish (US)
Pages (from-to)521-526
Number of pages6
JournalInternal Medicine
Volume47
Issue number6
DOIs
StatePublished - 2008

Fingerprint

Microscopic Polyangiitis
Ruptured Aneurysm
Antineutrophil Cytoplasmic Antibodies
Hepatic Artery
Renal Artery
Kidney
Aneurysm
Renal Dialysis
Angiography
Hemorrhage
Lung
Hypesthesia
Nephritis
Methylprednisolone
Glomerulonephritis
Prednisolone
Peripheral Nerves
General Hospitals
Hematoma
Renal Insufficiency

Keywords

  • ANCA-associated vasculitis
  • Arterial aneurysm
  • Bleeding complication
  • Microscopic polyangitis

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Tamei, N., Sugiura, H., Takei, T., Itabashi, M., Uchida, K., & Nitta, K. (2008). Ruptured arterial aneurysm of the kidney in a patient with microscopic polyangiitis. Internal Medicine, 47(6), 521-526. https://doi.org/10.2169/internalmedicine.47.0624

Ruptured arterial aneurysm of the kidney in a patient with microscopic polyangiitis. / Tamei, Noriko; Sugiura, Hidekazu; Takei, Takashi; Itabashi, Mitsuyo; Uchida, Keiko; Nitta, Kosaku.

In: Internal Medicine, Vol. 47, No. 6, 2008, p. 521-526.

Research output: Contribution to journalArticle

Tamei, N, Sugiura, H, Takei, T, Itabashi, M, Uchida, K & Nitta, K 2008, 'Ruptured arterial aneurysm of the kidney in a patient with microscopic polyangiitis', Internal Medicine, vol. 47, no. 6, pp. 521-526. https://doi.org/10.2169/internalmedicine.47.0624
Tamei, Noriko ; Sugiura, Hidekazu ; Takei, Takashi ; Itabashi, Mitsuyo ; Uchida, Keiko ; Nitta, Kosaku. / Ruptured arterial aneurysm of the kidney in a patient with microscopic polyangiitis. In: Internal Medicine. 2008 ; Vol. 47, No. 6. pp. 521-526.
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