S49 lymphoma wild type and variant clones contain normal calcium dependent regulator

W. H. Burgess, A. C. Howlett, R. H. Kretsinger, A. G. Gilman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Calcium dependent regulator is present in wild-type S49 lymphoma cells, in the variant that is deficient in adenylate cyclase activity (AC-), and in the uncoupled variant (UNC). The electrophoretic mobility and the ability to stimulate cyclic nucleotide phosphodiesterase of the calcium dependent regulator from each of these 3 clones are indistinguishable from those of the modulator protein isolated from bovine brain. Calcium dependent regulator does not appear to be involved in the defect responsible for the UNC or AC- variants.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalJournal of Cyclic Nucleotide Research
Volume4
Issue number3
Publication statusPublished - 1978

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Burgess, W. H., Howlett, A. C., Kretsinger, R. H., & Gilman, A. G. (1978). S49 lymphoma wild type and variant clones contain normal calcium dependent regulator. Journal of Cyclic Nucleotide Research, 4(3), 175-181.