Safety and efficacy of plasma exchange in pediatric transverse myelitis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background We sought to review safety and efficacy of therapeutic plasma exchange (TPE) in a cohort of pediatric patients with transverse myelitis. Methods Billing data of all plasma exchanges performed at our tertiary care pediatric hospital between August 2010 and August 2016 were compared to electronic medical records to find all patients whose indication for apheresis was transverse myelitis. Patient outcomes were quantified on the modified Rankin Scale. Results Fifteen of 19 patients (79%) had major improvement in symptoms after a course of 4-7 therapeutic plasma exchanges. The majority required further inpatient (6, 32%) or outpatient (8, 42%) physical therapy. Four (21%) patients returned to baseline and over 75% regained their ability to ambulate as of last follow-up. Four adverse events were noted over 114 treatments. Conclusions TPE can be a useful treatment for pediatric transverse myelitis. The retrospective nature of this study without a comparator group limits conclusions about efficacy. However, controlled trials would help to validate our results. Classification of evidence This study provides Class IV evidence that plasma exchange is safe and effective in pediatric transverse myelitis.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalNeurology: Clinical Practice
Volume8
Issue number4
DOIs
StatePublished - Aug 1 2018

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Transverse Myelitis
Plasma Exchange
Pediatrics
Safety
Therapeutics
Blood Component Removal
Pediatric Hospitals
Electronic Health Records
Tertiary Healthcare
Inpatients
Outpatients
Retrospective Studies

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Safety and efficacy of plasma exchange in pediatric transverse myelitis. / Noland, Daniel K; Greenberg, Benjamin.

In: Neurology: Clinical Practice, Vol. 8, No. 4, 01.08.2018, p. 327-330.

Research output: Contribution to journalArticle

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