Salivary acinic cell carcinoma: reappraisal and update

V. Vander Poorten, A. Triantafyllou, L. D.R. Thompson, J. Bishop, E. Hauben, J. Hunt, A. Skalova, G. Stenman, R. P. Takes, D. R. Gnepp, H. Hellquist, B. Wenig, D. Bell, A. Rinaldo, A. Ferlito

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

Original languageEnglish (US)
Pages (from-to)3511-3531
Number of pages21
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume273
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • Acinic cell carcinoma
  • Mammary analog secretory carcinoma
  • Pathology
  • Prognosis
  • Salivary glands
  • Therapy

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Salivary acinic cell carcinoma: reappraisal and update'. Together they form a unique fingerprint.

  • Cite this

    Vander Poorten, V., Triantafyllou, A., Thompson, L. D. R., Bishop, J., Hauben, E., Hunt, J., Skalova, A., Stenman, G., Takes, R. P., Gnepp, D. R., Hellquist, H., Wenig, B., Bell, D., Rinaldo, A., & Ferlito, A. (2016). Salivary acinic cell carcinoma: reappraisal and update. European Archives of Oto-Rhino-Laryngology, 273(11), 3511-3531. https://doi.org/10.1007/s00405-015-3855-7