Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection

Chenglin Ye; Qiao Li; Xinyi Li; Chae Gyu Park; Yingxia He; Yingmiao Zhang; Bicong Wu; Ying Xue; Kun Yang; Yin Lv; Xiao Ling Ying; Hong Hui Ding; Huahua Cai; Ayman Ahmad Alkraiem; Olivia Njiri; John Tembo; Hong Ping Huang; An Yi Li; Jianping Gong; Jichao Qin; Bing Cheng; Xiang Wei; Ziyong Sun; Shu Sheng Zhang; Pei Zhang; Guo Xing Zheng; Wei Li; Biao Kan; Meiying Yan; Xiamu Xiding; Xixiang Huo; Yingchun Zeng; Hua Peng; Yangxin Fu; John D. Klena; Mikael Skurnik; Ling Yu Jiang; Tie Chen

doi:10.1128/IAI.00100-19

Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection

Chenglin Ye, Qiao Li, Xinyi Li, Chae Gyu Park, Yingxia He, Yingmiao Zhang, Bicong Wu, Ying Xue, Kun Yang, Yin Lv, Xiao Ling Ying, Hong Hui Ding, Huahua Cai, Ayman Ahmad Alkraiem, Olivia Njiri, John Tembo, Hong Ping Huang, An Yi Li, Jianping Gong, Jichao QinBing Cheng, Xiang Wei, Ziyong Sun, Shu Sheng Zhang, Pei Zhang, Guo Xing Zheng, Wei Li, Biao Kan, Meiying Yan, Xiamu Xiding, Xixiang Huo, Yingchun Zeng, Hua Peng, Yangxin Fu, John D. Klena, Mikael Skurnik, Ling Yu Jiang, Tie Chen

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.

Original language	English (US)
Article number	e00100
Journal	Infection and immunity
Volume	87
Issue number	8
DOIs	https://doi.org/10.1128/IAI.00100-19
State	Published - 2019

Keywords

CD209
Dendritic cell
Dissemination
Lipooligosaccharide
Macrophages
S. Typhimurium

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

Access to Document

10.1128/IAI.00100-19

Cite this

Ye, C., Li, Q., Li, X., Park, C. G., He, Y., Zhang, Y., Wu, B., Xue, Y., Yang, K., Lv, Y., Ying, X. L., Ding, H. H., Cai, H., Alkraiem, A. A., Njiri, O., Tembo, J., Huang, H. P., Li, A. Y., Gong, J., ... Chen, T. (2019). Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection. Infection and immunity, 87(8), Article e00100. https://doi.org/10.1128/IAI.00100-19

Ye, C, Li, Q, Li, X, Park, CG, He, Y, Zhang, Y, Wu, B, Xue, Y, Yang, K, Lv, Y, Ying, XL, Ding, HH, Cai, H, Alkraiem, AA, Njiri, O, Tembo, J, Huang, HP, Li, AY, Gong, J, Qin, J, Cheng, B, Wei, X, Sun, Z, Zhang, SS, Zhang, P, Zheng, GX, Li, W, Kan, B, Yan, M, Xiding, X, Huo, X, Zeng, Y, Peng, H, Fu, Y, Klena, JD, Skurnik, M, Jiang, LY & Chen, T 2019, 'Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection', Infection and immunity, vol. 87, no. 8, e00100. https://doi.org/10.1128/IAI.00100-19

@article{b8adec92945140b28c25952458296545,

title = "Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection",

abstract = "Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.",

keywords = "CD209, Dendritic cell, Dissemination, Lipooligosaccharide, Macrophages, S. Typhimurium",

author = "Chenglin Ye and Qiao Li and Xinyi Li and Park, {Chae Gyu} and Yingxia He and Yingmiao Zhang and Bicong Wu and Ying Xue and Kun Yang and Yin Lv and Ying, {Xiao Ling} and Ding, {Hong Hui} and Huahua Cai and Alkraiem, {Ayman Ahmad} and Olivia Njiri and John Tembo and Huang, {Hong Ping} and Li, {An Yi} and Jianping Gong and Jichao Qin and Bing Cheng and Xiang Wei and Ziyong Sun and Zhang, {Shu Sheng} and Pei Zhang and Zheng, {Guo Xing} and Wei Li and Biao Kan and Meiying Yan and Xiamu Xiding and Xixiang Huo and Yingchun Zeng and Hua Peng and Yangxin Fu and Klena, {John D.} and Mikael Skurnik and Jiang, {Ling Yu} and Tie Chen",

note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China (NSFC 81271780 and 81471915 [T.C.] and 81602722 [L.-Y.J.]) and by two local grants from Tongji Hospital, Tongji Medical College (T.C.). C.G.P. was supported by grants from the National Research Foundation of Korea (NRF-2013R1A1A2058427 and NRF-2014R1A4A1008625) and a faculty research grant from Yonsei University College of Medicine for 2014 (6-2014-0062). Publisher Copyright: {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",

year = "2019",

doi = "10.1128/IAI.00100-19",

language = "English (US)",

volume = "87",

journal = "Infection and immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection

AU - Ye, Chenglin

AU - Li, Qiao

AU - Li, Xinyi

AU - Park, Chae Gyu

AU - He, Yingxia

AU - Zhang, Yingmiao

AU - Wu, Bicong

AU - Xue, Ying

AU - Yang, Kun

AU - Lv, Yin

AU - Ying, Xiao Ling

AU - Ding, Hong Hui

AU - Cai, Huahua

AU - Alkraiem, Ayman Ahmad

AU - Njiri, Olivia

AU - Tembo, John

AU - Huang, Hong Ping

AU - Li, An Yi

AU - Gong, Jianping

AU - Qin, Jichao

AU - Cheng, Bing

AU - Wei, Xiang

AU - Sun, Ziyong

AU - Zhang, Shu Sheng

AU - Zhang, Pei

AU - Zheng, Guo Xing

AU - Li, Wei

AU - Kan, Biao

AU - Yan, Meiying

AU - Xiding, Xiamu

AU - Huo, Xixiang

AU - Zeng, Yingchun

AU - Peng, Hua

AU - Fu, Yangxin

AU - Klena, John D.

AU - Skurnik, Mikael

AU - Jiang, Ling Yu

AU - Chen, Tie

N1 - Funding Information: This work was supported by grants from the National Natural Science Foundation of China (NSFC 81271780 and 81471915 [T.C.] and 81602722 [L.-Y.J.]) and by two local grants from Tongji Hospital, Tongji Medical College (T.C.). C.G.P. was supported by grants from the National Research Foundation of Korea (NRF-2013R1A1A2058427 and NRF-2014R1A4A1008625) and a faculty research grant from Yonsei University College of Medicine for 2014 (6-2014-0062). Publisher Copyright: © 2019 American Society for Microbiology. All Rights Reserved.

PY - 2019

Y1 - 2019

N2 - Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.

AB - Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.

KW - CD209

KW - Dendritic cell

KW - Dissemination

KW - Lipooligosaccharide

KW - Macrophages

KW - S. Typhimurium

UR - http://www.scopus.com/inward/record.url?scp=85070421241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070421241&partnerID=8YFLogxK

U2 - 10.1128/IAI.00100-19

DO - 10.1128/IAI.00100-19

M3 - Article

C2 - 31085704

AN - SCOPUS:85070421241

SN - 0019-9567

VL - 87

JO - Infection and immunity

JF - Infection and immunity

IS - 8

M1 - e00100

ER -

Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this