Salt Loading Blunts Central and Peripheral Postexercise Hypotension

Matthew C. Babcock, Austin T. Robinson, Joseph C. Watso, Kamila U. Migdal, Christopher R. Martens, David G. Edwards, Linda S. Pescatello, William B. Farquhar

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Introduction High salt intake is a widespread cardiovascular risk factor with systemic effects. These effects include an expansion of plasma volume, which may interfere with postexercise hypotension (PEH). However, the effects of high salt intake on central and peripheral indices of PEH remain unknown. We tested the hypothesis that high salt intake would attenuate central and peripheral PEH. Methods Nineteen healthy adults (7 female/12 male; age, 25 ± 4 yr; body mass index, 23.3 ± 2.2 kg·m-2; VO2peak, 41.6 ± 8.7 mL·min-1·kg-1; systolic blood pressure (BP), 112 ± 9 mm Hg; diastolic BP, 65 ± 9 mm Hg) participated in this double-blind, randomized, placebo-controlled crossover study. Participants were asked to maintain a 2300 mg·d-1 sodium diet for 10 d on two occasions separated by ≥2 wk. Total salt intake was manipulated via ingestion of capsules containing either table salt (3900 mg·d-1) or placebo (dextrose) during each diet. On the 10th day, participants completed 50 min of cycling at 60% VO2peak. A subset of participants (n = 8) completed 60 min of seated rest (sham trial). Beat-to-beat BP was measured in-laboratory for 60 min after exercise via finger photoplethysmography. Brachial and central BPs were measured for 24 h after exercise via ambulatory BP monitor. Results Ten days of high salt intake increased urinary sodium excretion (134 ± 70 (dextrose) vs 284 ± 74 mmol per 24 h (salt), P < 0.001), expanded plasma volume (7.2% ± 10.8%), and abolished PEH during in-laboratory BP monitoring (main effect of diet, P < 0.001). Ambulatory systolic BPs were higher for 12 h after exercise during the salt and sham trials compared with the dextrose trial (average change, 3.6 ± 2.1 mm Hg (dextrose), 9.9 ± 1.4 mm Hg (salt), 9.8 ± 2.5 mm Hg (sham); P = 0.01). Ambulatory central systolic BP was also higher during the salt trial compared with dextrose trial. Conclusion High salt intake attenuates peripheral and central PEH, potentially reducing the beneficial cardiovascular effects of acute aerobic exercise.

Original languageEnglish (US)
Pages (from-to)935-943
Number of pages9
JournalMedicine and science in sports and exercise
Volume52
Issue number4
DOIs
StatePublished - Apr 1 2020
Externally publishedYes

Keywords

  • AEROBIC EXERCISE
  • BRACHIAL BLOOD PRESSURE
  • CENTRAL BLOOD PRESSURE
  • POSTEXERCISE HYPOTENSION
  • SALT

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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