Salt-sensitive hypertension in transgenic mice overexpressing Na+-proton exchanger

M. Kuro-o, K. Hanaoka, Y. Hiroi, T. Noguchi, Y. Fujimori, S. I. Takewaki -, M. Hayasaka, H. Katoh, A. Miyagishi, R. Nagai, Y. Yazaki, Y. I. Nabeshima

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Essential hypertension is one of the most common diseases that exacerbate the risk of cardiovascular or cerebrovascular attacks. Although the etiology of essential hypertension remains unclear, recent investigations have revealed that an enhancement of Na+-proton (Na+-H+) exchange activity is a frequently observed ion transport abnormality in hypertensive patients and animal models. To test the hypothesis that increased Na+-H+ exchange causes hypertension, we produced transgenic mice overexpressing Na+-H+ exchanger and analyzed their Na+ metabolism and blood pressure. Urinary excretion of water and Na+ was significantly decreased in transgenic mice, and systolic blood pressure was elevated after salt loading. The impaired urinary excretion of Na+ suggested that the Na+-H+ exchanger overexpressed in the renal tubules increased reabsorption of Na+, which caused a blood pressure elevation by Na+ retention after excessive salt intake. Our results demonstrate that overexpression of Na+-H+ exchanger can be a genetic factor that interacts with excessive salt intake and causes salt-sensitive blood pressure elevation.

Original languageEnglish (US)
Pages (from-to)148-153
Number of pages6
JournalCirculation research
Volume76
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • Na-proton exchanger
  • hypertension
  • overexpression
  • transgenic mouse

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Kuro-o, M., Hanaoka, K., Hiroi, Y., Noguchi, T., Fujimori, Y., Takewaki -, S. I., Hayasaka, M., Katoh, H., Miyagishi, A., Nagai, R., Yazaki, Y., & Nabeshima, Y. I. (1995). Salt-sensitive hypertension in transgenic mice overexpressing Na+-proton exchanger. Circulation research, 76(1), 148-153. https://doi.org/10.1161/01.res.76.1.148