Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Sihan Wu, Paul S. Mischel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

Original languageEnglish (US)
Pages (from-to)311-313
Number of pages3
JournalCancer Cell
Volume38
Issue number3
DOIs
StatePublished - Sep 14 2020
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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