Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Sihan Wu; Paul S. Mischel

doi:10.1016/j.ccell.2020.08.012

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Sihan Wu, Paul S. Mischel

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

Original language	English (US)
Pages (from-to)	311-313
Number of pages	3
Journal	Cancer Cell
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2020.08.012
State	Published - Sep 14 2020
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2020.08.012

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title = "Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma",

abstract = "Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.",

author = "Sihan Wu and Mischel, {Paul S.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

day = "14",

doi = "10.1016/j.ccell.2020.08.012",

language = "English (US)",

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journal = "Cancer Cell",

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T1 - Same Script, Different Cast

T2 - Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

AU - Wu, Sihan

AU - Mischel, Paul S.

PY - 2020/9/14

Y1 - 2020/9/14

N2 - Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

AB - Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

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U2 - 10.1016/j.ccell.2020.08.012

DO - 10.1016/j.ccell.2020.08.012

M3 - Comment/debate

C2 - 32931740

AN - SCOPUS:85090932422

SN - 1535-6108

VL - 38

SP - 311

EP - 313

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Abstract

ASJC Scopus subject areas

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