Sarcomas

Josephine H. HaDuong, Andrew A. Martin, Stephen X. Skapek, Leo Mascarenhas

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Malignant bone tumors (osteosarcoma, Ewing sarcoma) and soft-tissue sarcomas (rhabdomyosarcoma, nonrhabdomyosarcoma) account for approximately 14% of childhood malignancies. Successful treatment of patients with sarcoma depends on a multidisciplinary approach to therapy, including oncology, surgery, radiation oncology, radiology, pathology, and physiatry. By combining systemic treatment with chemotherapy and primary tumor control using surgery and/or radiation, survival rates for localized disease range from 70% to 75%. However, children with metastatic or recurrent disease continue to have dismal outcomes. A better understanding of the biology underlying both bone and soft-tissue sarcomas is required to further improve outcomes for children with these tumors.

Original languageEnglish (US)
Pages (from-to)179-200
Number of pages22
JournalPediatric clinics of North America
Volume62
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Bone
  • Ewing's
  • Nonrhabdomyosarcoma
  • Osteosarcoma
  • Rhabdomyosarcoma
  • Soft-tissue sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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