Abstract
Malignant bone tumors (osteosarcoma, Ewing sarcoma) and soft-tissue sarcomas (rhabdomyosarcoma, nonrhabdomyosarcoma) account for approximately 14% of childhood malignancies. Successful treatment of patients with sarcoma depends on a multidisciplinary approach to therapy, including oncology, surgery, radiation oncology, radiology, pathology, and physiatry. By combining systemic treatment with chemotherapy and primary tumor control using surgery and/or radiation, survival rates for localized disease range from 70% to 75%. However, children with metastatic or recurrent disease continue to have dismal outcomes. A better understanding of the biology underlying both bone and soft-tissue sarcomas is required to further improve outcomes for children with these tumors.
Original language | English (US) |
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Pages (from-to) | 179-200 |
Number of pages | 22 |
Journal | Pediatric clinics of North America |
Volume | 62 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2015 |
Keywords
- Bone
- Ewing's
- Nonrhabdomyosarcoma
- Osteosarcoma
- Rhabdomyosarcoma
- Soft-tissue sarcoma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health