SARS-CoV-2 Immunohistochemistry In Placenta

Dinesh Rakheja, Kristina Treat, Charles F. Timmons, Deyssy Carrillo, Sara E. Miller, Edana Stroberg, Lisa M. Barton, Eric J. Duval, Sanjay Mukhopadhyay

Research output: Contribution to journalArticlepeer-review

Abstract

Compared to the parental SARS-CoV-2 virus, infections by the now dominant Delta variant of SARS-CoV-2 appear to be more common and more severe in pregnant women. The need for a robust, cheap, and quick method for diagnosing placental infection by SARS-CoV-2 has thus become more acute. Here, we describe a highly sensitive and specific immunohistochemical assay for SARS-CoV-2 nucleocapsid protein for routine use in placental pathology practice.

Original languageEnglish (US)
JournalInternational Journal of Surgical Pathology
DOIs
StateAccepted/In press - 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • electron microscopy
  • immunohistochemistry
  • nucleocapsid protein
  • placenta
  • spike protein
  • ultrastructure

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine

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