Abstract
MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MAP kinase module, is organized on scaffolds with a variety of forms and functions. This review discusses similarities and differences in scaffolding proteins and mechanisms in yeast, flies, worms and mammals.
Original language | English (US) |
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Pages (from-to) | 219-226 |
Number of pages | 8 |
Journal | Cell Calcium |
Volume | 26 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1999 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology