Scaffolding and protein interactions in MAP kinase modules

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Abstract

MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MAP kinase module, is organized on scaffolds with a variety of forms and functions. This review discusses similarities and differences in scaffolding proteins and mechanisms in yeast, flies, worms and mammals.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalCell Calcium
Volume26
Issue number5
DOIs
Publication statusPublished - Nov 1999

Cite this

Scaffolding and protein interactions in MAP kinase modules. / Karandikar, M.; Cobb, M. H.

In: Cell Calcium, Vol. 26, No. 5, 11.1999, p. 219-226.

Research output: Contribution to journalArticle