Scavenger receptor WC1 contributes to the γδ T cell response to Leptospira

Fei Wang, Carolyn T A Herzig, Chuang Chen, Haoting Hsu, Cynthia L. Baldwin, Janice C. Telfer

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

WC1 molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multi-gene family. WC1 molecules have been grouped on the basis of antibody reactivity. The expression of WC1 molecules from these serologically defined groups is correlated with differences in γδ T cell responses. The expression of receptors within the WC1.1 group correlates with the capacity of γδ T cells to respond to Leptospira antigen. In this study, we used RNA interference to directly investigate the role of WC1 expression in the response to Leptospira borgpetersenii. We found that when three out of thirteen WC1 gene products were downregulated by RNA interference, γδ T cell proliferation and IFN-γ production in response to Leptospira antigen was significantly reduced. Our data demonstrate that specific receptors in the WC1 family directly participate in Leptospira recognition and/or activation of γδ T cells.

Original languageEnglish (US)
Pages (from-to)801-809
Number of pages9
JournalMolecular Immunology
Volume48
Issue number6-7
DOIs
StatePublished - Mar 1 2011

Keywords

  • Bovine
  • Leptospira
  • SRCR
  • WC1
  • γδ T cells

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Scavenger receptor WC1 contributes to the γδ T cell response to Leptospira'. Together they form a unique fingerprint.

  • Cite this

    Wang, F., Herzig, C. T. A., Chen, C., Hsu, H., Baldwin, C. L., & Telfer, J. C. (2011). Scavenger receptor WC1 contributes to the γδ T cell response to Leptospira. Molecular Immunology, 48(6-7), 801-809. https://doi.org/10.1016/j.molimm.2010.12.001