Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations

J. W. Maas, C. L. Bowden, A. L. Miller, M. A. Javors, L. G. Funderburg, N. Berman, S. T. Weintraub

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Neuroleptic drugs block brain dopamine receptors and are effective in treating psychoses of diverse origins. This finding has become a cornerstone of the dopamine theory of schizophrenia, but clinical studies relating schizophrenia, per se, to brain dopamine metabolism have ranged from controversial to negative. This article presents new evidence that cerebrospinal fluid levels of the dopamine metabolite homovanillic acid are related to the severity of psychosis in schizophrenia. These results support the concept that homovanillic acid levels in cerebrospinal fluid vary as a function of psychosis rather than being related to the diagnosis of schizophrenia per se.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalSchizophrenia Bulletin
Volume23
Issue number1
StatePublished - 1997

Fingerprint

psychoses
schizophrenia
Homovanillic Acid
dopamine
Psychotic Disorders
Schizophrenia
cerebrospinal fluid
Cerebrospinal fluid
Fluid
Dopamine
acids
Fluids
Acids
fluids
Metabolism
Receptor
brain
Cerebrospinal Fluid
Brain
Drugs

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Radiation
  • Radiological and Ultrasound Technology

Cite this

Maas, J. W., Bowden, C. L., Miller, A. L., Javors, M. A., Funderburg, L. G., Berman, N., & Weintraub, S. T. (1997). Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations. Schizophrenia Bulletin, 23(1), 147-154.

Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations. / Maas, J. W.; Bowden, C. L.; Miller, A. L.; Javors, M. A.; Funderburg, L. G.; Berman, N.; Weintraub, S. T.

In: Schizophrenia Bulletin, Vol. 23, No. 1, 1997, p. 147-154.

Research output: Contribution to journalArticle

Maas, JW, Bowden, CL, Miller, AL, Javors, MA, Funderburg, LG, Berman, N & Weintraub, ST 1997, 'Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations', Schizophrenia Bulletin, vol. 23, no. 1, pp. 147-154.
Maas JW, Bowden CL, Miller AL, Javors MA, Funderburg LG, Berman N et al. Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations. Schizophrenia Bulletin. 1997;23(1):147-154.
Maas, J. W. ; Bowden, C. L. ; Miller, A. L. ; Javors, M. A. ; Funderburg, L. G. ; Berman, N. ; Weintraub, S. T. / Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations. In: Schizophrenia Bulletin. 1997 ; Vol. 23, No. 1. pp. 147-154.
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