Schizophrenic symptoms improve with apomorphine

Carol A. Tamminga, Martin H. Schaffer, Robert C. Smith, John M. Davis

Research output: Contribution to journalArticle

191 Scopus citations


Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

Original languageEnglish (US)
Pages (from-to)567-568
Number of pages2
Issue number4341
StatePublished - Jan 1 1978


ASJC Scopus subject areas

  • General

Cite this

Tamminga, C. A., Schaffer, M. H., Smith, R. C., & Davis, J. M. (1978). Schizophrenic symptoms improve with apomorphine. Science, 200(4341), 567-568.