Schizophrenic symptoms improve with apomorphine

Carol A. Tamminga, Martin H. Schaffer, Robert C. Smith, John M. Davis

Research output: Contribution to journalArticlepeer-review

191 Scopus citations

Abstract

Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

Original languageEnglish (US)
Pages (from-to)567-568
Number of pages2
JournalScience
Volume200
Issue number4341
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • General

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