SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

Camille Tlemsani, Lorinc Pongor, Fathi Elloumi, Luc Girard, Kenneth E. Huffman, Nitin Roper, Sudhir Varma, Augustin Luna, Vinodh N. Rajapakse, Robin Sebastian, Kurt W. Kohn, Julia Krushkal, Mirit I. Aladjem, Beverly A. Teicher, Paul S. Meltzer, William C. Reinhold, John D. Minna, Anish Thomas, Yves Pommier

Research output: Contribution to journalArticlepeer-review

Abstract

Tlemsani et al. provide a unique resource, SCLC-CellMiner, integrating drug sensitivity and multi-omics data from 118 small cell lung cancer (SCLC) cell lines. They demonstrate that SCLCs have differential transcriptional networks driven by lineage-specific transcription factors (NEUROD1, ASCL1, POU2F3, and YAP1). Furthermore, YAP1-driven SCLCs have distinct drug sensitivity profiles.

Original languageEnglish (US)
Article number108296
JournalCell Reports
Volume33
Issue number3
DOIs
StatePublished - Oct 20 2020

Keywords

  • genomics
  • immune checkpoints
  • mutations
  • native immune response
  • neuroendocrine tumors
  • PARP
  • replication
  • Schlafen
  • SLFN11
  • STING

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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