Scleredema

Leonard L. Madison

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Since 1900 when scleredema was described by Buschke a total of 107 cases have been reported with but few exceptions in the foreign literature. The disease is characterized by the appearance of brawny, nonpitting, painless edema usually starting on the neck and rapidly spreading by continuity to the head, chest and back. Although the abdomen and extremities may be involved, the hands and feet are spared. The disease is preceded by a febrile illness, usually a streptococcal infection, and commonly undergoes spontaneous involution without sequelae within three to eighteen months. Systemic involvement, including pleural, pericardial and joint effusions, has recently been stressed. Twenty-seven per cent of the cases occurred within the first decade and females were involved more frequently than males. The present case showed the unusual findings of parotid involvement, possible pericardial involvement and, microscopically, early neutrophilic perivascular infiltration. Encouraging results with epinephrine therapy were noted, and the possibility of more dramatic therapeutic response with the 11,17-oxysteroids proven to be of value in other diffuse collagen diseases has been discussed.

Original languageEnglish (US)
Pages (from-to)707-713
Number of pages7
JournalThe American journal of medicine
Volume9
Issue number5
StatePublished - Nov 1950

Fingerprint

Scleredema Adultorum
Collagen Diseases
Streptococcal Infections
Pericardial Effusion
Abdomen
Epinephrine
Foot
Edema
Fever
Neck
Thorax
Extremities
Hand
Joints
Head
Therapeutics

ASJC Scopus subject areas

  • Nursing(all)
  • Medicine(all)

Cite this

Madison, L. L. (1950). Scleredema. The American journal of medicine, 9(5), 707-713.

Scleredema. / Madison, Leonard L.

In: The American journal of medicine, Vol. 9, No. 5, 11.1950, p. 707-713.

Research output: Contribution to journalArticle

Madison, LL 1950, 'Scleredema', The American journal of medicine, vol. 9, no. 5, pp. 707-713.
Madison LL. Scleredema. The American journal of medicine. 1950 Nov;9(5):707-713.
Madison, Leonard L. / Scleredema. In: The American journal of medicine. 1950 ; Vol. 9, No. 5. pp. 707-713.
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