Sclerosing Polycystic Adenoma

Justin A. Bishop, Lester D.R. Thompson

Research output: Contribution to journalReview articlepeer-review

Abstract

Sclerosing polycystic adenoma (SPA) is the more appropriate name for sclerosing polycystic adenosis. SPA is an uncommon salivary gland lesion with a constellation of unusual histologic findings that were originally interpreted as analogous to breast fibrocystic changes. The histologic findings in SPA include fibrosis, cystic alterations, apocrine metaplasia, and proliferations of ducts, acini, and myoepithelial cells in variable proportions. Because of its unusual mixed histology, SPA may be confused with a variety of lesions, ranging from reactive conditions to benign or even malignant neoplasms. The features of SPA are reviewed, with an emphasis on resolving its differential diagnosis.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalSurgical Pathology Clinics
Volume14
Issue number1
DOIs
StatePublished - Mar 2021

Keywords

  • PI3 kinase
  • Parotid gland
  • Salivary glands
  • Sclerosing polycystic adenoma
  • Sclerosing polycystic adenosis

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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