Screening for Autism spectrum disorders in extremely preterm infants

Bonnie E. Stephens, Carla M. Bann, Victoria E. Watson, Stephen J. Sheinkopf, Myriam Peralta-Carcelen, Anna Bodnar, Kimberly Yolton, Ricki F. Goldstein, Anna M. Dusick, Deanne E. Wilson-Costello, Michael J. Acarregui, Athina Pappas, Ira Adams-Chapman, Elisabeth C. McGowan, Roy J. Heyne, Susan R. Hintz, Richard A. Ehrenkranz, Janell Fuller, Abhik Das, Rosemary D. Higgins & 1 others Betty R. Vohr

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Extremely preterm (EP) infants screen positive for autism spectrum disorders (ASD) at high rates. However, it is not clear whether this is because of high rates of ASD in EPs or to high rates of false-positive screens for ASD in children with a high rate of underlying neurodevelopmental impairments. Combining a parent questionnaire designed to distinguish developmental delay from ASD with direct observation of infant behavior may more accurately screen for ASD in EPs. Objectives: To determine rates of positive screen for ASD at 18 to 22 months(m) in EPs using 3 screens; to determine factors associated with a positive screen. Methods: Five hundred fifty-four infants born <27 weeks were screened at 18 to 22 m using the Pervasive Developmental Disorders Screening test, second edition Stage 2, and the response to name and response to joint attention items from the Autism Diagnostic Observation Schedule. Infants with severe cerebral palsy, deafness, and blindness were excluded. Associations between positive screen and neonatal/infant characteristics were determined. Results: Of 554 infants, 113 (20%) had 1 positive screen. 10% had a positive Pervasive Developmental Disorders Screening test, second edition, 6% response to name, 9% response to joint attention; in only 1 % all 3 screens were positive. Positive screen was associated with male gender, more hospital days, white race, lower maternal education, abnormal behavioral scores, and cognitive/language delay. Conclusions: The use of 3 screens for ASD in EPs results in higher screen positive rates than use of 1 screen alone. Diagnostic confirmation is needed before true rates of ASD in EPs are known.

Original languageEnglish (US)
Pages (from-to)535-541
Number of pages7
JournalJournal of Developmental and Behavioral Pediatrics
Volume33
Issue number7
DOIs
StatePublished - Sep 2012

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Extremely Premature Infants
Names
Deaf-Blind Disorders
Observation
Infant Behavior
Language Development Disorders
Autism Spectrum Disorder
Cerebral Palsy
Autistic Disorder
Appointments and Schedules
Mothers
Education

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Stephens, B. E., Bann, C. M., Watson, V. E., Sheinkopf, S. J., Peralta-Carcelen, M., Bodnar, A., ... Vohr, B. R. (2012). Screening for Autism spectrum disorders in extremely preterm infants. Journal of Developmental and Behavioral Pediatrics, 33(7), 535-541. https://doi.org/10.1097/DBP.0b013e31825fd0af

Screening for Autism spectrum disorders in extremely preterm infants. / Stephens, Bonnie E.; Bann, Carla M.; Watson, Victoria E.; Sheinkopf, Stephen J.; Peralta-Carcelen, Myriam; Bodnar, Anna; Yolton, Kimberly; Goldstein, Ricki F.; Dusick, Anna M.; Wilson-Costello, Deanne E.; Acarregui, Michael J.; Pappas, Athina; Adams-Chapman, Ira; McGowan, Elisabeth C.; Heyne, Roy J.; Hintz, Susan R.; Ehrenkranz, Richard A.; Fuller, Janell; Das, Abhik; Higgins, Rosemary D.; Vohr, Betty R.

In: Journal of Developmental and Behavioral Pediatrics, Vol. 33, No. 7, 09.2012, p. 535-541.

Research output: Contribution to journalArticle

Stephens, BE, Bann, CM, Watson, VE, Sheinkopf, SJ, Peralta-Carcelen, M, Bodnar, A, Yolton, K, Goldstein, RF, Dusick, AM, Wilson-Costello, DE, Acarregui, MJ, Pappas, A, Adams-Chapman, I, McGowan, EC, Heyne, RJ, Hintz, SR, Ehrenkranz, RA, Fuller, J, Das, A, Higgins, RD & Vohr, BR 2012, 'Screening for Autism spectrum disorders in extremely preterm infants', Journal of Developmental and Behavioral Pediatrics, vol. 33, no. 7, pp. 535-541. https://doi.org/10.1097/DBP.0b013e31825fd0af
Stephens BE, Bann CM, Watson VE, Sheinkopf SJ, Peralta-Carcelen M, Bodnar A et al. Screening for Autism spectrum disorders in extremely preterm infants. Journal of Developmental and Behavioral Pediatrics. 2012 Sep;33(7):535-541. https://doi.org/10.1097/DBP.0b013e31825fd0af
Stephens, Bonnie E. ; Bann, Carla M. ; Watson, Victoria E. ; Sheinkopf, Stephen J. ; Peralta-Carcelen, Myriam ; Bodnar, Anna ; Yolton, Kimberly ; Goldstein, Ricki F. ; Dusick, Anna M. ; Wilson-Costello, Deanne E. ; Acarregui, Michael J. ; Pappas, Athina ; Adams-Chapman, Ira ; McGowan, Elisabeth C. ; Heyne, Roy J. ; Hintz, Susan R. ; Ehrenkranz, Richard A. ; Fuller, Janell ; Das, Abhik ; Higgins, Rosemary D. ; Vohr, Betty R. / Screening for Autism spectrum disorders in extremely preterm infants. In: Journal of Developmental and Behavioral Pediatrics. 2012 ; Vol. 33, No. 7. pp. 535-541.
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abstract = "Background: Extremely preterm (EP) infants screen positive for autism spectrum disorders (ASD) at high rates. However, it is not clear whether this is because of high rates of ASD in EPs or to high rates of false-positive screens for ASD in children with a high rate of underlying neurodevelopmental impairments. Combining a parent questionnaire designed to distinguish developmental delay from ASD with direct observation of infant behavior may more accurately screen for ASD in EPs. Objectives: To determine rates of positive screen for ASD at 18 to 22 months(m) in EPs using 3 screens; to determine factors associated with a positive screen. Methods: Five hundred fifty-four infants born <27 weeks were screened at 18 to 22 m using the Pervasive Developmental Disorders Screening test, second edition Stage 2, and the response to name and response to joint attention items from the Autism Diagnostic Observation Schedule. Infants with severe cerebral palsy, deafness, and blindness were excluded. Associations between positive screen and neonatal/infant characteristics were determined. Results: Of 554 infants, 113 (20{\%}) had 1 positive screen. 10{\%} had a positive Pervasive Developmental Disorders Screening test, second edition, 6{\%} response to name, 9{\%} response to joint attention; in only 1 {\%} all 3 screens were positive. Positive screen was associated with male gender, more hospital days, white race, lower maternal education, abnormal behavioral scores, and cognitive/language delay. Conclusions: The use of 3 screens for ASD in EPs results in higher screen positive rates than use of 1 screen alone. Diagnostic confirmation is needed before true rates of ASD in EPs are known.",
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AU - Stephens, Bonnie E.

AU - Bann, Carla M.

AU - Watson, Victoria E.

AU - Sheinkopf, Stephen J.

AU - Peralta-Carcelen, Myriam

AU - Bodnar, Anna

AU - Yolton, Kimberly

AU - Goldstein, Ricki F.

AU - Dusick, Anna M.

AU - Wilson-Costello, Deanne E.

AU - Acarregui, Michael J.

AU - Pappas, Athina

AU - Adams-Chapman, Ira

AU - McGowan, Elisabeth C.

AU - Heyne, Roy J.

AU - Hintz, Susan R.

AU - Ehrenkranz, Richard A.

AU - Fuller, Janell

AU - Das, Abhik

AU - Higgins, Rosemary D.

AU - Vohr, Betty R.

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N2 - Background: Extremely preterm (EP) infants screen positive for autism spectrum disorders (ASD) at high rates. However, it is not clear whether this is because of high rates of ASD in EPs or to high rates of false-positive screens for ASD in children with a high rate of underlying neurodevelopmental impairments. Combining a parent questionnaire designed to distinguish developmental delay from ASD with direct observation of infant behavior may more accurately screen for ASD in EPs. Objectives: To determine rates of positive screen for ASD at 18 to 22 months(m) in EPs using 3 screens; to determine factors associated with a positive screen. Methods: Five hundred fifty-four infants born <27 weeks were screened at 18 to 22 m using the Pervasive Developmental Disorders Screening test, second edition Stage 2, and the response to name and response to joint attention items from the Autism Diagnostic Observation Schedule. Infants with severe cerebral palsy, deafness, and blindness were excluded. Associations between positive screen and neonatal/infant characteristics were determined. Results: Of 554 infants, 113 (20%) had 1 positive screen. 10% had a positive Pervasive Developmental Disorders Screening test, second edition, 6% response to name, 9% response to joint attention; in only 1 % all 3 screens were positive. Positive screen was associated with male gender, more hospital days, white race, lower maternal education, abnormal behavioral scores, and cognitive/language delay. Conclusions: The use of 3 screens for ASD in EPs results in higher screen positive rates than use of 1 screen alone. Diagnostic confirmation is needed before true rates of ASD in EPs are known.

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