Screening prostate cancer using a portable near infrared scanning imaging unit with an optical fiber-based rectal probe

Yang Pu, Wubao Wang, Guichen Tang, Yury Budansky, Mikhail Sharonov, Min Xu, Samuel Achilefu, James A. Eastham, Robert R. Alfano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

A portable near infrared scanning polarization imaging unit with an optical fiber-based rectal probe, namely Photonic Finger, was designed and developed o locate the 3D position of abnormal prostate site inside normal prostate tissue. An inverse algorithm, Optical Tomography using Independent Component Analysis (OPTICA) was improved particularly to unmix the signal from targets (cancerous tissue) embedded in a turbid medium (normal tissue) in the backscattering imaging geometry. Photonic Finger combined with OPTICA was tested to characterize different target(s) inside different tissue medium, including cancerous prostate tissue embedded by large piece of normal tissue.

Original languageEnglish (US)
Title of host publicationOptical Biopsy X
DOIs
StatePublished - 2012
Externally publishedYes
EventOptical Biopsy X - San Francisco, CA, United States
Duration: Jan 24 2012Jan 25 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8220
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy X
Country/TerritoryUnited States
CitySan Francisco, CA
Period1/24/121/25/12

Keywords

  • backscattering
  • human prostate tissue
  • Independent Component Analysis (ICA)
  • multiple angular view
  • optical fiber-based rectal probe
  • photon propagation model
  • Photonic Finger (PF)
  • receptor-target contrast agent
  • scanning optical polarization imaging
  • three-dimensional localization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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