Screening women at high risk for breast cancer with mammography and magnetic resonance imaging

Constance D. Lehman, Jeffrey D. Blume, Paul Weatherall, David Thickman, Nola Hylton, Ellen Warner, Etta Pisano, Stuart J. Schnitt, Constantine Gatsonis, Mitchell Schnall

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

BACKGROUND. The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. METHODS. The authors conducted an international prospective study of screening mammography and MRI in asymptomatic, genetically high-risk women age a 25 years. Women with a history of breast cancer were eligible for a contralateral screening if they had been diagnosed within 5 years or a bilateral screening if they had been diagnosed > 5 years previously. All examinations (MRI, mammography, and clinical breast examination [CBE]) were performed within 90 days of each other. RESULTS. In total, 390 eligible women were enrolled by 13 sites, and 367 women completed all study examinations. Imaging evaluations recommended 38 biopsies, and 27 biopsies were performed, resulting in 4 cancers diagnosed for an overall 1.1% cancer yield (95% confidence interval [95%CI], 0.3-2.8%). MRI detected all four cancers, whereas mammography detected one cancer. The diagnostic yield of mammography was 0.3% (95%CI, 0.01-1.5%). The yield of cancer by MRI alone was 0.8% (95%CI, - 0.3-2.0%). The biopsy recommendation rates for MRI and mammography were 8.5% (95%CI, 5.8-11.8%) and 2.2% (95%CI, 0.1-4.3%). CONCLUSIONS. Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer. Screening MRI resulted in 22 of 367 of women (6%) who had negative mammogram and negative CBE examinations undergoing biopsy, resulting in 3 additional cancers detected. MRI also resulted in 19 (5%) false-positive outcomes, which resulted in benign biopsies.

Original languageEnglish (US)
Pages (from-to)1898-1905
Number of pages8
JournalCancer
Volume103
Issue number9
DOIs
StatePublished - May 1 2005

Fingerprint

Mammography
Magnetic Resonance Imaging
Breast Neoplasms
Confidence Intervals
Biopsy
Neoplasms
Breast
Prospective Studies

Keywords

  • Breast cancer
  • High risk
  • Magnetic resonance imaging
  • Screening

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lehman, C. D., Blume, J. D., Weatherall, P., Thickman, D., Hylton, N., Warner, E., ... Schnall, M. (2005). Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer, 103(9), 1898-1905. https://doi.org/10.1002/cncr.20971

Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. / Lehman, Constance D.; Blume, Jeffrey D.; Weatherall, Paul; Thickman, David; Hylton, Nola; Warner, Ellen; Pisano, Etta; Schnitt, Stuart J.; Gatsonis, Constantine; Schnall, Mitchell.

In: Cancer, Vol. 103, No. 9, 01.05.2005, p. 1898-1905.

Research output: Contribution to journalArticle

Lehman, CD, Blume, JD, Weatherall, P, Thickman, D, Hylton, N, Warner, E, Pisano, E, Schnitt, SJ, Gatsonis, C & Schnall, M 2005, 'Screening women at high risk for breast cancer with mammography and magnetic resonance imaging', Cancer, vol. 103, no. 9, pp. 1898-1905. https://doi.org/10.1002/cncr.20971
Lehman, Constance D. ; Blume, Jeffrey D. ; Weatherall, Paul ; Thickman, David ; Hylton, Nola ; Warner, Ellen ; Pisano, Etta ; Schnitt, Stuart J. ; Gatsonis, Constantine ; Schnall, Mitchell. / Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. In: Cancer. 2005 ; Vol. 103, No. 9. pp. 1898-1905.
@article{eabb86bd684441a5a78b953a4018aa27,
title = "Screening women at high risk for breast cancer with mammography and magnetic resonance imaging",
abstract = "BACKGROUND. The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. METHODS. The authors conducted an international prospective study of screening mammography and MRI in asymptomatic, genetically high-risk women age a 25 years. Women with a history of breast cancer were eligible for a contralateral screening if they had been diagnosed within 5 years or a bilateral screening if they had been diagnosed > 5 years previously. All examinations (MRI, mammography, and clinical breast examination [CBE]) were performed within 90 days of each other. RESULTS. In total, 390 eligible women were enrolled by 13 sites, and 367 women completed all study examinations. Imaging evaluations recommended 38 biopsies, and 27 biopsies were performed, resulting in 4 cancers diagnosed for an overall 1.1{\%} cancer yield (95{\%} confidence interval [95{\%}CI], 0.3-2.8{\%}). MRI detected all four cancers, whereas mammography detected one cancer. The diagnostic yield of mammography was 0.3{\%} (95{\%}CI, 0.01-1.5{\%}). The yield of cancer by MRI alone was 0.8{\%} (95{\%}CI, - 0.3-2.0{\%}). The biopsy recommendation rates for MRI and mammography were 8.5{\%} (95{\%}CI, 5.8-11.8{\%}) and 2.2{\%} (95{\%}CI, 0.1-4.3{\%}). CONCLUSIONS. Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer. Screening MRI resulted in 22 of 367 of women (6{\%}) who had negative mammogram and negative CBE examinations undergoing biopsy, resulting in 3 additional cancers detected. MRI also resulted in 19 (5{\%}) false-positive outcomes, which resulted in benign biopsies.",
keywords = "Breast cancer, High risk, Magnetic resonance imaging, Screening",
author = "Lehman, {Constance D.} and Blume, {Jeffrey D.} and Paul Weatherall and David Thickman and Nola Hylton and Ellen Warner and Etta Pisano and Schnitt, {Stuart J.} and Constantine Gatsonis and Mitchell Schnall",
year = "2005",
month = "5",
day = "1",
doi = "10.1002/cncr.20971",
language = "English (US)",
volume = "103",
pages = "1898--1905",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Screening women at high risk for breast cancer with mammography and magnetic resonance imaging

AU - Lehman, Constance D.

AU - Blume, Jeffrey D.

AU - Weatherall, Paul

AU - Thickman, David

AU - Hylton, Nola

AU - Warner, Ellen

AU - Pisano, Etta

AU - Schnitt, Stuart J.

AU - Gatsonis, Constantine

AU - Schnall, Mitchell

PY - 2005/5/1

Y1 - 2005/5/1

N2 - BACKGROUND. The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. METHODS. The authors conducted an international prospective study of screening mammography and MRI in asymptomatic, genetically high-risk women age a 25 years. Women with a history of breast cancer were eligible for a contralateral screening if they had been diagnosed within 5 years or a bilateral screening if they had been diagnosed > 5 years previously. All examinations (MRI, mammography, and clinical breast examination [CBE]) were performed within 90 days of each other. RESULTS. In total, 390 eligible women were enrolled by 13 sites, and 367 women completed all study examinations. Imaging evaluations recommended 38 biopsies, and 27 biopsies were performed, resulting in 4 cancers diagnosed for an overall 1.1% cancer yield (95% confidence interval [95%CI], 0.3-2.8%). MRI detected all four cancers, whereas mammography detected one cancer. The diagnostic yield of mammography was 0.3% (95%CI, 0.01-1.5%). The yield of cancer by MRI alone was 0.8% (95%CI, - 0.3-2.0%). The biopsy recommendation rates for MRI and mammography were 8.5% (95%CI, 5.8-11.8%) and 2.2% (95%CI, 0.1-4.3%). CONCLUSIONS. Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer. Screening MRI resulted in 22 of 367 of women (6%) who had negative mammogram and negative CBE examinations undergoing biopsy, resulting in 3 additional cancers detected. MRI also resulted in 19 (5%) false-positive outcomes, which resulted in benign biopsies.

AB - BACKGROUND. The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. METHODS. The authors conducted an international prospective study of screening mammography and MRI in asymptomatic, genetically high-risk women age a 25 years. Women with a history of breast cancer were eligible for a contralateral screening if they had been diagnosed within 5 years or a bilateral screening if they had been diagnosed > 5 years previously. All examinations (MRI, mammography, and clinical breast examination [CBE]) were performed within 90 days of each other. RESULTS. In total, 390 eligible women were enrolled by 13 sites, and 367 women completed all study examinations. Imaging evaluations recommended 38 biopsies, and 27 biopsies were performed, resulting in 4 cancers diagnosed for an overall 1.1% cancer yield (95% confidence interval [95%CI], 0.3-2.8%). MRI detected all four cancers, whereas mammography detected one cancer. The diagnostic yield of mammography was 0.3% (95%CI, 0.01-1.5%). The yield of cancer by MRI alone was 0.8% (95%CI, - 0.3-2.0%). The biopsy recommendation rates for MRI and mammography were 8.5% (95%CI, 5.8-11.8%) and 2.2% (95%CI, 0.1-4.3%). CONCLUSIONS. Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer. Screening MRI resulted in 22 of 367 of women (6%) who had negative mammogram and negative CBE examinations undergoing biopsy, resulting in 3 additional cancers detected. MRI also resulted in 19 (5%) false-positive outcomes, which resulted in benign biopsies.

KW - Breast cancer

KW - High risk

KW - Magnetic resonance imaging

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=20244374837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20244374837&partnerID=8YFLogxK

U2 - 10.1002/cncr.20971

DO - 10.1002/cncr.20971

M3 - Article

C2 - 15800894

AN - SCOPUS:20244374837

VL - 103

SP - 1898

EP - 1905

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -