Searching Chromatin for Stem Cell Identity

Michael Buszczak, Allan C. Spradling

Research output: Contribution to journalShort survey

77 Scopus citations

Abstract

Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue homeostasis, regeneration, aging, and oncogenesis.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalCell
Volume125
Issue number2
DOIs
StatePublished - Apr 21 2006

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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