TY - JOUR
T1 - Searching for genes underlying behavior
T2 - Lessons from circadian rhythms
AU - Takahashi, Joseph S.
AU - Shimomura, Kazuhiro
AU - Kumar, Vivek
PY - 2008/11/7
Y1 - 2008/11/7
N2 - The success of forward genetic (from phenotype to gene) approaches to uncover genes that drive the molecular mechanism of circadian clocks and control circadian behavior has been unprecedented. Links among genes, cells, neural circuits, and circadian behavior have been uncovered in the Drosophila and mammalian systems, demonstrating the feasibility of finding single genes that have major effects on behavior. Why was this approach so successful in the elucidation of circadian rhythms? This article explores the answers to this question and describes how the methods used successfully for identifying the molecular basis of circadian rhythms can be applied to other behaviors such as anxiety, addiction, and learning and memory.
AB - The success of forward genetic (from phenotype to gene) approaches to uncover genes that drive the molecular mechanism of circadian clocks and control circadian behavior has been unprecedented. Links among genes, cells, neural circuits, and circadian behavior have been uncovered in the Drosophila and mammalian systems, demonstrating the feasibility of finding single genes that have major effects on behavior. Why was this approach so successful in the elucidation of circadian rhythms? This article explores the answers to this question and describes how the methods used successfully for identifying the molecular basis of circadian rhythms can be applied to other behaviors such as anxiety, addiction, and learning and memory.
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U2 - 10.1126/science.1158822
DO - 10.1126/science.1158822
M3 - Review article
C2 - 18988844
AN - SCOPUS:55849149439
SN - 0036-8075
VL - 322
SP - 909
EP - 912
JO - Science
JF - Science
IS - 5903
ER -