Searching for genes underlying behavior

Lessons from circadian rhythms

Joseph S. Takahashi, Kazuhiro Shimomura, Vivek Kumar

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The success of forward genetic (from phenotype to gene) approaches to uncover genes that drive the molecular mechanism of circadian clocks and control circadian behavior has been unprecedented. Links among genes, cells, neural circuits, and circadian behavior have been uncovered in the Drosophila and mammalian systems, demonstrating the feasibility of finding single genes that have major effects on behavior. Why was this approach so successful in the elucidation of circadian rhythms? This article explores the answers to this question and describes how the methods used successfully for identifying the molecular basis of circadian rhythms can be applied to other behaviors such as anxiety, addiction, and learning and memory.

Original languageEnglish (US)
Pages (from-to)909-912
Number of pages4
JournalScience
Volume322
Issue number5903
DOIs
StatePublished - Nov 7 2008

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Circadian Rhythm
Genes
Circadian Clocks
Behavior Control
Drosophila
Anxiety
Learning
Phenotype

ASJC Scopus subject areas

  • General

Cite this

Searching for genes underlying behavior : Lessons from circadian rhythms. / Takahashi, Joseph S.; Shimomura, Kazuhiro; Kumar, Vivek.

In: Science, Vol. 322, No. 5903, 07.11.2008, p. 909-912.

Research output: Contribution to journalArticle

Takahashi, Joseph S. ; Shimomura, Kazuhiro ; Kumar, Vivek. / Searching for genes underlying behavior : Lessons from circadian rhythms. In: Science. 2008 ; Vol. 322, No. 5903. pp. 909-912.
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