Sec61β - A component of the archaeal protein secretory system

Lisa N. Kinch, Milton H. Saier, Nick V. Grishin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61β has been detected. With the identification of the Sec61β motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.

Original languageEnglish (US)
Pages (from-to)170-171
Number of pages2
JournalTrends in Biochemical Sciences
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2002

Fingerprint

Archaeal Proteins
Archaea
Protein Transport
Eukaryota
Bacteria
Membranes
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

Sec61β - A component of the archaeal protein secretory system. / Kinch, Lisa N.; Saier, Milton H.; Grishin, Nick V.

In: Trends in Biochemical Sciences, Vol. 27, No. 4, 01.04.2002, p. 170-171.

Research output: Contribution to journalArticle

Kinch, Lisa N. ; Saier, Milton H. ; Grishin, Nick V. / Sec61β - A component of the archaeal protein secretory system. In: Trends in Biochemical Sciences. 2002 ; Vol. 27, No. 4. pp. 170-171.
@article{202efc4de82d4bcdaa2feffc09b45822,
title = "Sec61β - A component of the archaeal protein secretory system",
abstract = "Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61β has been detected. With the identification of the Sec61β motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.",
author = "Kinch, {Lisa N.} and Saier, {Milton H.} and Grishin, {Nick V.}",
year = "2002",
month = "4",
day = "1",
doi = "10.1016/S0968-0004(01)02055-2",
language = "English (US)",
volume = "27",
pages = "170--171",
journal = "Trends in Biochemical Sciences",
issn = "0376-5067",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Sec61β - A component of the archaeal protein secretory system

AU - Kinch, Lisa N.

AU - Saier, Milton H.

AU - Grishin, Nick V.

PY - 2002/4/1

Y1 - 2002/4/1

N2 - Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61β has been detected. With the identification of the Sec61β motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.

AB - Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61β has been detected. With the identification of the Sec61β motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.

UR - http://www.scopus.com/inward/record.url?scp=0036525752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036525752&partnerID=8YFLogxK

U2 - 10.1016/S0968-0004(01)02055-2

DO - 10.1016/S0968-0004(01)02055-2

M3 - Article

VL - 27

SP - 170

EP - 171

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0376-5067

IS - 4

ER -