Sec61β - A component of the archaeal protein secretory system

Lisa N. Kinch, Milton H. Saier, Nick V. Grishin

Research output: Contribution to journalArticle

36 Scopus citations


Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61β has been detected. With the identification of the Sec61β motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.

Original languageEnglish (US)
Pages (from-to)170-171
Number of pages2
JournalTrends in Biochemical Sciences
Issue number4
StatePublished - Apr 1 2002


ASJC Scopus subject areas

  • Biochemistry

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