Secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer

John O. Schorge, Shana N. Wingo, Rafia Bhore, Thomas P. Heffernan, Jayanthi S. Lea

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: To determine the risks and benefits of secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer. Methods: Data were obtained retrospectively for all women with recurrent platinum-sensitive epithelial ovarian cancer who underwent a second debulking operation between 1998 and 2008 at the University of Texas Southwestern Medical Center. Survival analysis and comparisons were performed using the Kaplan-Meier method, log-rank test, and Cox multivariate proportional hazards model. Results: Optimal secondary cytoreductive surgery (< 5 mm of residual disease) was achieved in 32 of 40 patients (80%). Nine women (23%) developed major complications. Two variables, residual disease of less than 5 mm vs 5 mm or greater (median 63 months vs 11 months; P = 0.003); and less than 5 vs 5 or more sites of disease relapse (median 63 months vs 22 months; P = 0.009), were independently associated with survival and retained prognostic significance on multivariate analysis. Conclusions: Optimal secondary cytoreductive surgery was associated with a survival advantage and acceptable risks.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Volume108
Issue number2
DOIs
StatePublished - Feb 2010

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Platinum
Ovarian Neoplasms
Survival
Survival Analysis
Proportional Hazards Models
Multivariate Analysis
Recurrence

Keywords

  • Recurrent ovarian cancer
  • Secondary cytoreductive surgery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer. / Schorge, John O.; Wingo, Shana N.; Bhore, Rafia; Heffernan, Thomas P.; Lea, Jayanthi S.

In: International Journal of Gynecology and Obstetrics, Vol. 108, No. 2, 02.2010, p. 123-127.

Research output: Contribution to journalArticle

Schorge, John O. ; Wingo, Shana N. ; Bhore, Rafia ; Heffernan, Thomas P. ; Lea, Jayanthi S. / Secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer. In: International Journal of Gynecology and Obstetrics. 2010 ; Vol. 108, No. 2. pp. 123-127.
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