Secretory autophagy of lysozyme in Paneth cells

Shai Bel, Lora V. Hooper

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Secretion of antimicrobial proteins is an important host defense mechanism against bacteria, yet how secretory cells maintain function during bacterial invasion has been unclear. We discovered that Paneth cells, specialized secretory cells in the small intestine, react to bacterial invasion by rerouting a critical secreted antibacterial protein through a macroautophagy/autophagy-based secretion system termed secretory autophagy. Mice harboring a mutation in an essential autophagy gene, a mutation which is common in Crohn disease patients, cannot reroute their antimicrobial cargo during bacterial invasion and thus have compromised innate immunity. We showed that this alternative secretion system is triggered by both a cell-intrinsic mechanism, involving the ER stress response, and a cell-extrinsic mechanism, involving subepithelial innate immune cells. Our findings uncover a new role for secretory autophagy in host defense and suggest how a mutation in an autophagy gene can predispose individuals to Crohn disease.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalAutophagy
DOIs
StateAccepted/In press - Mar 1 2018

Fingerprint

Paneth Cells
Autophagy
Muramidase
Crohn Disease
Mutation
Essential Genes
Innate Immunity
Small Intestine
Proteins
Bacteria
Genes

Keywords

  • antimicrobial
  • ATG16L1
  • autophagy
  • Crohn's disease
  • lysozyme
  • microbiota
  • Salmonella Typhimurium
  • secretion
  • secretory autophagy
  • unconventional secretion

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Secretory autophagy of lysozyme in Paneth cells. / Bel, Shai; Hooper, Lora V.

In: Autophagy, 01.03.2018, p. 1-3.

Research output: Contribution to journalArticle

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