Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature

Megan A. Desai, Mitra Mehrad, Kim A. Ely, Justin Avery Bishop, James Netterville, Joseph M. Aulino, James S. Lewis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

After being described in the salivary glands as a malignancy with features essentially identical to those of the breast, secretory carcinoma (SC) (formerly mammary analogue SC) has now been identified in other sites including the skin, lung, and thyroid gland. In the breast, SC has a relatively favorable prognosis. Likewise when arising in the salivary glands, it is generally considered to be a low to intermediate grade carcinoma; however, there is a range of clinical behavior with occasional patients dying of progressive disease. SCs of the thyroid gland are rare, and reports suggest a relatively aggressive behavior, at least relative to well differentiated carcinomas such as papillary carcinoma and minimally invasive follicular carcinoma. We present a patient with a highly aggressive thyroid gland SC that mimicked undifferentiated carcinoma clinically. The patient had widespread metastatic disease and died rapidly from airway compromise. We also review the literature for reported cases of thyroid gland SC in order to better establish the clinical features and expected clinical course of such tumors occurring at this site.

Original languageEnglish (US)
JournalHead and Neck Pathology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Thyroid Gland
Carcinoma
Salivary Glands
Papillary Carcinoma
Neoplasms
Breast
Lung
Skin

Keywords

  • Anaplastic carcinoma
  • ETV6 gene rearrangement
  • Mammary analogue secretory carcinoma
  • Papillary carcinoma
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Cite this

Secretory Carcinoma of the Thyroid Gland : Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature. / Desai, Megan A.; Mehrad, Mitra; Ely, Kim A.; Bishop, Justin Avery; Netterville, James; Aulino, Joseph M.; Lewis, James S.

In: Head and Neck Pathology, 01.01.2018.

Research output: Contribution to journalArticle

@article{fab4b8b7d5194463a7a3ae580cb84267,
title = "Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature",
abstract = "After being described in the salivary glands as a malignancy with features essentially identical to those of the breast, secretory carcinoma (SC) (formerly mammary analogue SC) has now been identified in other sites including the skin, lung, and thyroid gland. In the breast, SC has a relatively favorable prognosis. Likewise when arising in the salivary glands, it is generally considered to be a low to intermediate grade carcinoma; however, there is a range of clinical behavior with occasional patients dying of progressive disease. SCs of the thyroid gland are rare, and reports suggest a relatively aggressive behavior, at least relative to well differentiated carcinomas such as papillary carcinoma and minimally invasive follicular carcinoma. We present a patient with a highly aggressive thyroid gland SC that mimicked undifferentiated carcinoma clinically. The patient had widespread metastatic disease and died rapidly from airway compromise. We also review the literature for reported cases of thyroid gland SC in order to better establish the clinical features and expected clinical course of such tumors occurring at this site.",
keywords = "Anaplastic carcinoma, ETV6 gene rearrangement, Mammary analogue secretory carcinoma, Papillary carcinoma, Thyroid",
author = "Desai, {Megan A.} and Mitra Mehrad and Ely, {Kim A.} and Bishop, {Justin Avery} and James Netterville and Aulino, {Joseph M.} and Lewis, {James S.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s12105-018-0995-2",
language = "English (US)",
journal = "Head and Neck Pathology",
issn = "1936-055X",
publisher = "Humana Press",

}

TY - JOUR

T1 - Secretory Carcinoma of the Thyroid Gland

T2 - Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature

AU - Desai, Megan A.

AU - Mehrad, Mitra

AU - Ely, Kim A.

AU - Bishop, Justin Avery

AU - Netterville, James

AU - Aulino, Joseph M.

AU - Lewis, James S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - After being described in the salivary glands as a malignancy with features essentially identical to those of the breast, secretory carcinoma (SC) (formerly mammary analogue SC) has now been identified in other sites including the skin, lung, and thyroid gland. In the breast, SC has a relatively favorable prognosis. Likewise when arising in the salivary glands, it is generally considered to be a low to intermediate grade carcinoma; however, there is a range of clinical behavior with occasional patients dying of progressive disease. SCs of the thyroid gland are rare, and reports suggest a relatively aggressive behavior, at least relative to well differentiated carcinomas such as papillary carcinoma and minimally invasive follicular carcinoma. We present a patient with a highly aggressive thyroid gland SC that mimicked undifferentiated carcinoma clinically. The patient had widespread metastatic disease and died rapidly from airway compromise. We also review the literature for reported cases of thyroid gland SC in order to better establish the clinical features and expected clinical course of such tumors occurring at this site.

AB - After being described in the salivary glands as a malignancy with features essentially identical to those of the breast, secretory carcinoma (SC) (formerly mammary analogue SC) has now been identified in other sites including the skin, lung, and thyroid gland. In the breast, SC has a relatively favorable prognosis. Likewise when arising in the salivary glands, it is generally considered to be a low to intermediate grade carcinoma; however, there is a range of clinical behavior with occasional patients dying of progressive disease. SCs of the thyroid gland are rare, and reports suggest a relatively aggressive behavior, at least relative to well differentiated carcinomas such as papillary carcinoma and minimally invasive follicular carcinoma. We present a patient with a highly aggressive thyroid gland SC that mimicked undifferentiated carcinoma clinically. The patient had widespread metastatic disease and died rapidly from airway compromise. We also review the literature for reported cases of thyroid gland SC in order to better establish the clinical features and expected clinical course of such tumors occurring at this site.

KW - Anaplastic carcinoma

KW - ETV6 gene rearrangement

KW - Mammary analogue secretory carcinoma

KW - Papillary carcinoma

KW - Thyroid

UR - http://www.scopus.com/inward/record.url?scp=85058927254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058927254&partnerID=8YFLogxK

U2 - 10.1007/s12105-018-0995-2

DO - 10.1007/s12105-018-0995-2

M3 - Article

C2 - 30564997

AN - SCOPUS:85058927254

JO - Head and Neck Pathology

JF - Head and Neck Pathology

SN - 1936-055X

ER -