Seizures due to maprotiline overdose

Laurel Northup, Gary Reed, Bill McAnalley, Ron J. Anderson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Maprotiline, a new tetracyclic antidepressant, has a pattern of toxicity that is different from that of tricyclics. Maprotiline overdosage appears more likely to cause seizures but less likely to cause the peripheral autonomic and cardiac manifestations seen with tricyclics. Two cases of maprotiline overdose resulting in seizures without significant anticholinergic or cardiotoxic effects are presented. Both patients were treated acutely with gastric emptying and were observed to have no further seizures during subsequent drug-free hospital and outpatient follow up. Physostigmine salicylate has been used as an antidote for the anticholinergic syndrome of tricyclic overdose, but probably offers less in maprotiline overdose. Careful observation for seizures appears to be warranted.

Original languageEnglish (US)
Pages (from-to)468-470
Number of pages3
JournalAnnals of Emergency Medicine
Volume13
Issue number6
DOIs
StatePublished - 1984

Fingerprint

Maprotiline
Seizures
Anticholinergic Syndrome
Antidotes
Gastric Emptying
Cholinergic Antagonists
Antidepressive Agents
Outpatients
Observation
Pharmaceutical Preparations

Keywords

  • antidepressant, maprotiline, overdose
  • drug overdose, maprotiline
  • maprotiline, overdose

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Seizures due to maprotiline overdose. / Northup, Laurel; Reed, Gary; McAnalley, Bill; Anderson, Ron J.

In: Annals of Emergency Medicine, Vol. 13, No. 6, 1984, p. 468-470.

Research output: Contribution to journalArticle

Northup, L, Reed, G, McAnalley, B & Anderson, RJ 1984, 'Seizures due to maprotiline overdose', Annals of Emergency Medicine, vol. 13, no. 6, pp. 468-470. https://doi.org/10.1016/S0196-0644(84)80016-5
Northup, Laurel ; Reed, Gary ; McAnalley, Bill ; Anderson, Ron J. / Seizures due to maprotiline overdose. In: Annals of Emergency Medicine. 1984 ; Vol. 13, No. 6. pp. 468-470.
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