Selective depletion of radiolabeled HER2-specific antibody for contrast improvement during PET

Priyanka Khare, Wei Sun, Sreevidhya Ramakrishnan, Guiyang Hao, Su Tang Lo, Kien Nham, Xiankai Sun, Raimund J. Ober, E. Sally Ward, Rafal Swiercz

Research output: Contribution to journalArticlepeer-review

Abstract

The prolonged in vivo persistence of antibodies results in high background and poor contrast during their use as molecular imaging agents for positron emission tomography (PET). We have recently described a class of engineered Fc fusion proteins that selectively deplete antigen-specific antibodies without affecting the levels of antibodies of other specificities. Here, we demonstrate that these Fc fusions (called Seldegs, for selective degradation) can be used to clear circulating, radiolabeled HER2-specific antibody during diagnostic imaging of HER2-positive tumors in mice. The analyses show that Seldegs have considerable promise for the reduction of whole-body exposure to radiolabel and improvement of contrast during PET.

Original languageEnglish (US)
Article number1976705
JournalmAbs
Volume13
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Engineered Fc fusions
  • HER2
  • PET

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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